University:
Coventry University
Course:
115 BMS | Introduction to Biomedical Analysis
Academic year:

2024
Views:

362

Pages:

5
Author:

Badusha S

Introduction: -Iodinated contrast agents wed in the cardiac catheter zakon laboratory are the mainstay of visualizations of Cerovaly and bripheral vasculature as well as candidac anatomy low cavalier and foo-osmaler agents have been developed to miligale adverse events white Moulding and fruaging Deferitis: - radiographed contrast media or agents are soo-chance that are used to visualize structures or diseased processes that would otherwise be inupside or difficult to see during diagnostic vadised praging. -They are pharmaceuticals that aller haque characteristics to enharca infarmahos oblewed on diagnosis Mago. Hyperosmalarity 아 - when P hyperosmolar diye meras with blood, it absorbs water freas Roc's & the RBC's shrink. chelators of cat airlyttima genic - a hyperosmolar agent is intensely vasodilating w peripheral pooling & reduced reves perlapan-CIN - Vasodilation stimulates paranasal nociceptive neve eadings, which results in pato. -direct injury to aldo Hallom, some of the vasodilators lile Hilaixie kallikrapus are vescublexic at high conc. -Intravenous contrast medico caves a significant increase to seros osmolality, Candice cutput and unile outpat. Types of contrast agente: Vaxtoo fermelaton of contest agant contadung Fadere have boos developed. They believe in tonicity and the ratto of Podule to particles. Thes ratio directly affects their viscosity and csinolarily. 1st presentation high osmolar antiest media: (HOCN) -These Yome wollathers whob consist of single, negatudy charged iodinated benzene vlug attached to a carbon. -lo delle provides the radio pacily. osmolarity & is determined by the no. of particles in a solution rather than partide size. -The particles dissociate is solutions thes 3: 2 Padin to partick ratio. creating a 1st generatas agents have to bleed but a sodino concentration spelar Lyreros malere relative to dood. -These agents have asinador Phy that is typically $1900mCoin/ kg compared with the 290 mOsm/kg band in blood. - This high osmolality can cause repolarization changes and arly minutes during CAS. of -both the fine city and hyperos molarity of there agant contribute to significant volume shifts and to adverse carle and renal affects. -Thex include bradycardia, Av black, VF and acute kidney eg: diatrizoate (hypaque, angporist, venografth) Metit zoate (sopaque) Pothalamati (canxay) spots Moto and generation, low last meter contest modea: (LOCH) stored to infni miye the side threats. the list alles agents coses the Ponic demar Paxaglate Chexabits) (perligo) al - - loxaglat s Nono acidic double benzene ing with Stokke of sex molecules of Padure of the 24 66 an eads ring. a The ages can be wed to visualize the vasculature at an somnolently of 600 mOsm/leg, twice that of bloed, but less than half that of HOCN. -The LOCM wave was further developed in the renforo foam. - worlorene berry & honpone contrast agents que the Podinaled with many bydre photo hydroxyl groups have as and osmolality betwood 500 and 850 mesm/kg, two-three times that of blood. ante -Waber solide and without charge, the Manione. LOCH Could come les ventricular printability Has ils iome Predecessors, but generally have a higher is cocity - ne increased risk of carambola events compared with loka agent. -less heptiolarity and fever allergie eachas compared with HOCH.