Innate Immunity 1st layer of defense Physical barriers includes includes Chemical barriers Complement system Mucosal membranes Con sists of Stimulates Occurs in Produces Produces Phagocytes PAMPS and PRRS Hematopoiesis includes Macrophages uces Prod Neutrophils Chemotaxis Leads to Leads to Microbial infection Inflammatory cytokine production CD4 Th cells Secretes Completely eliminates Stimulates nizes Recog s antigend in te presen M BCR d H iffe C: re pe nt pt id es T cells of Provides ists Occurs in Lymphocytes sts nsi Co f o Cell-mediated immunity antig en presen s ted in MHC class II Cell proliferation TCR Leads to Cons MHC class I Antigen Produces Adaptive Immunity Thymus Clonal selection Occurs in V(D)J recombination Memory B and T cells Produces Humoral immunity CD8 T cell activation Secondary lymphoid organs Neutralization of pathogens or toxins Antibodies Provides Occurs in Antigen processing Provides Phagocytosis CD8 Tc cells CD4 T cell activation Primary lymphoid organs Stimulates Dendritic cells Leads to Immunological memory Lymphocyte development Protection against re-exposure Killing of intracellular bacteria Presented by Monocytes CD4 T cell differentiation Perforin and granzymes Leads to Natural Killer cells Recognizes Classical pathway connects to Somatic hypermutation Bone marrow Results in includes Membrane Attack Complex B cells Th1 cells, Th2 cellsand Treg cells Inflammation Initiates Opsonization Affinity maturation Class switching Antimicrobial proteins and peptides Killing of infected host cells Cellular innate responses Negative selection for T and B cells Epithelial barrier APCs Killing of extracellular bacteria Positive selection for T B cell activation Leads to TI and TD B cell reponse

Immune System Concept Map

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