University:
Eastern Kentucky University
Course:
CHE 431 | Metabolic Biochemistry
Academic year:

2020
Views:

129

Pages:

1
Author:

Kolten Khan

Appendix M: Gluconeogenesi Gluconeogenesis Takes place mainly in the liver and, to a lesser extent, in the kidneys Glucose Pi Glucose 6-phosphatase Found only in liver. H 2O Glucose 6-phosphate Phosphoglucose isomerase Fructose 6-phosphate Pi Fructose 1,6-bisphosphatase H 2O Control point of gluconeogenesis Activated by ATP, inhibited by AMP and fructose 2,6-bisphosphate. Fructose 1,6-bisphosphate Aldolase Dihydroxyacetone phosphate Triose phosphate isomerase Glyceraldehyde 3-phosphate Pi, NAD+ Glyceraldehyde 3-phosphate NADH dehydrogenase 1,3-Bisphosphoglycerate ADP Phosphoglycerate kinase ATP 3-Phosphoglycerate Phosphoglycerate mutase 2-Phosphoglycerate Enolase H 2O GDP, CO2 Phosphoenolpyruvate (PEP) GTP The combination of Pyruvate Carboxylase and PEPCK is used to circumvent the action of Pyruvate Kinase. Phosphoenolpyruvate Carboxykinase (PEPCK) Activated by glucagon and cortisol. Oxaloacetate Pyruvate ATP, HCO3 ADP + P Pyruvate Carboxylase Activated by Acetyl-CoA. Begins in mitochondria and uses malate as intermediate to exit the mitochondria.