University:
Eastern Kentucky University
Course:
CHE 431 | Metabolic Biochemistry
Academic year:

2020
Views:

464

Pages:

1
Author:

levedzgetmo7f

Appendix P: More Metabolic Pathway Fatty Acid Synthesis b -Oxidation Occurs in the cell’s cytoplasm Occurs in the mitochondrial matrix Fatty Acid Acyl-CoA FAD Reduce Oxidation FADH2 NADPH H 2O H 2O Dehydration Hydration NAD+ Reduce Oxidation NADH NADPH CoA, CO2 Initiation of Fatty Acid Synthesis 1. Fatty acid synthesis begins with the transfer of Acetyl-CoA from the mitochondria to the cytosol. 2. Activation of Acetyl-CoA through the synthesis of Malonyl-CoA. Enzyme is Acetyl-CoA Carboxylase (regulatory enzyme for fatty acid synthesis). 3. Malonyl-CoA elongation using ACR DR. CoA-SH Condense Acetyl-CoA attaches to Acyl Carrier Protein (ACP) Thiolysis Acetyl-CoA + (Acyl-CoA 2 carbons less Attach b -Oxidation Energy Products Malonyl-CoA Example: C16 Fatty Acid (C2) Acetyl-CoA =8 # Rounds of b -Oxidation = 7 NADH: 7 FADH2: 7 Urea Cycle Pentose Phosphate Pathway Occurs in the cytosol and mitochondrial matrix of liver. and its link to glycolysis. Occurs in cytosol. Fatty acid synthesis Citric Acid Cycle 2 NADP+ CO2 Fumarate Urea Ornithine Carbamoyl Phosphate + CO2 + NH4 Argininosuccinate Citrulline Aspartate Other reactions, such as detoxification Glucose 6-phosphate Ribulose 5-phosphate Fructose 6-phosphate Xylulose 5-phosphate Glyceraldehyde 3-phosphate Ribose 5-phosphate Nucleotide biosynthesis Oxaloacetate Mitochondrial Matrix Citric Acid Cycle Glutathione reduction Glucose H2O Arginine 2 NADPH Pyruvate Glycolysis Pentose Phosphate Pathway