University:
Jacksonville State University
Course:
BY 323 | Microbiology
Academic year:

2023
Views:

333

Pages:

2
Author:

Cannon Best

Antibiotics 30 subunit Aminoglycosides (Streptomycin, TB streptomycin, gentamycin, amikacin) Bactericidal, aerobic G-ve only RNA synthesis 50 subunit Macrolides (Erythromycin, clarithromycin, azithromycin) Bacteriostatic, translocation of peptides Clindamycin Bacteriostatic, peptide bond Chloramphenicol Bacteriostatic, MRSA, VRE Broad spectrum Telithromycin Bind at 2 sites of bacterial ribosome Clindamycin G+ve, G-ve, anaerobic bacteria Toxic shock syndrome (TSS) Pseudomembranous colitis DNA synth Fluoroquinolones (Ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin) DNA gyrase G+ve & G-ve Metronidazole Disrupt DNA Anaerobes and protozoa RNA synth Rifampicin Bind to DNA-dependent RNA polymerase Aerobic G+ve, mycobacterium TB, HIV, AIDS, Neisseria meningitidis, leprosy Prophylaxis for H. influenzae meningitis Polymyxins Bind to LPS and disrupt the outer membrane Gram-negative bacteria Last line drugs against multidrug-resistant bacteria β-lactam AB Peptidoglycan synthesis Step 1: D-alanine cross-linking Step 2: Peptidoglycan transpeptidase Step 3: Bacterial cell lysis Step 4: Resistance to β-lactam Penicillin Block cross-linkage G+ve, G-ve Bactericidal Cephalosporins Similar to penicillin G+ve (level I), G3-4, G-ve Bactericidal, ESBL MRSA, PRSP Carbapenems Imipenem Bactericidal / BS G+ve, G-ve, anaerobes Chlamydia Monobactam Aztreonam Aerobic G-ve Used with in Penicillin HS to penicillin Vancomycin Cell wall Early (4th) stage Transpeptidase Transglycosidase G+ve, MRSA, G-ve Can't cross G-ve cell wall Bacitracin Peptidoglycan cyclization G+ve, MRSA Isoniazid (INH) Mycobacteria Isonicotinic acid hydrazide Bacteriostatic Pyrazinamide Mycobacteria Ethambutol Mycobacteria Sulfonamide Trimethoprim