Antiviral Drugs Pharmacology Ill

University:
Kansas State University
Course:
BIOCH 765 | Biochemistry II
Academic year:

2014
Views:

463

Pages:

5
Author:

Jackdams

Antiviral Drugs Dear students You must be aware of Corona COVID -19 which is spreading viral infection and is being spread rapidly in many countries and we all are homestuck due to it. You must have also heard that it is not treated by antibiotics you know why? Beacause to deactivate an infection borne by virus we need antiviral drugs not the antibacterial drugs. Hence all those penicillin, cephalosporin, cotrimoxazole and others we learnt won't be able to deactivate any virus as they cannot inhibit them. So, children today we will learn about antiviral drugs. VIRUS Viruses are obligate intracellular parasites. They lack both a cell wall and a cell membrane, and they do not carry out metabolic processes. Viral reproduction uses much of the host's metabolic machinery, and few drugs are selective enough to prevent viral replication without injury to the host Therapy for viral diseases is further complicated by the fact that the clinical symptoms appear late in the course of the disease, at a time when most of the virus particles have replicated. [Note: This contrasts with bacterial diseases, in which the clinical symptoms are usually coincident with bacterial proliferation.] At this late, symptomatic stage of the viral infection, administration of drugs that block viral replication has limited effectiveness. However, some antiviral agents are useful as prophylactic agents. Only a few virus groups, including those that cause the viral infections discussed in this chapter, respond to available antiviral drugs. To assist in the review of these drugs, they are grouped according to the affected organisms. Antiviral Drugs Antiviral drug classification A Non-RetroV1ral Antiviral Agents 1 Ant1-herµesvirus Agents 2 Ant1-1nfluenza Agents 3 Ant1-hepat1t1s Agents B Antiretrov,ral Agents 1 Nucleos1de Reverse Transcnptase lnh1b1tors ( NRTI) 2 Non-nucleos1de Reverse Transrnptase lnh1b1tors I NNRTI l 3 Protease lnhtbtlOfS f Pl l 4 Entry lnh1b1tors 5 lntegrase Strand Transfer lnh1b1tors Classification of antiviral Agents 1.Anti-Herpes virus ldoJRS(NRTIS) Eg: Zidovudine (AZT) Stavudine Abacavir Lamivudin.e. It is the first drug to be used in the tre atment of HIV infection. l\lechanism of action: Zidovudine .,, Zidovudinc -tripho pbate Binds reverse transcriptase(RNA-dependent DNA polymerase) lnmrponte into viral DNA tin dudn termination

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