Biochemistry Test (Drugs Inspector MCQ) - Questions and Answers

2019 1. Which one of the foUowing families is known for presence of volatile oils in lrichomes ? A. Lauraceae B. Loganiaceae C. Labiatae (Ans) D. Leguminosae 2. Listed below are the chemical tests used to identify a group of pbytoconstituents. Identify the test for the detection of the purine alkaloids: A. Keller-KiUani Test B. Murex.ide Test (Ans) C. Shinoda Test D. Vitali-Morin Test 3. Atropine biosynthesis involves a pair of precw·sors. Identify the correct pair. A. Omitbine and phenylalanine (Ans) B. Tyrosine and Tryptopban C. Tryptophan and Dopamine D. Tyrosine and Dopamine 4. What is chemotaxis ? A. B. C. D. Toxicity of chemicals Taxonomy of chemicals Inhibition of inflammation Movement of leukocytes in inflammation (Ans) 5. Which one of the following antihistaminic agents causes cardiac dysrbythmias ? A. Fexofenadine B. Terfenadine (Ans) C. Cetiriz-ine D. Loratadine 6. Which one of the following is an oral anticoagulant ? A. Heparin B. Warfarin (Ans) C. Lepirudin D. Melgatran 7. Following is an example of the long acting broncbodilator : A. Salmeterol (Ans) B. Salbutamol C. Sotalol D. Montelukast 8. Following is an exam.le of anti-emetic drug acting on 5-HT3 receptors. A. Nabilone B. Ondansetron (Ans) C. Metoclopramide D. Domperidone 9. The combination of mifepristone and gemeprost is used for : A. Endometriosis B. EndometriaJ carcinoma C. Medical termination of regnancy D. Breast carcinoma. 10. Rifampicin, an anti mycobacterial agent acts on : A. B. C. D. DNA dependent DNA polymerase RNA dependent DNA polymerase DNA dependent RNA polymerase (Ans) RNA dependent RNA polymerase 11. An atni-schizophrenic agent having no extra-pyramidal side effects is A. Haloperidol B. Olenzapine (Ans) C. Thioxanthenes D. Pimozide 12.Which one of the following types of the glass containers should be used for packaging of human blood and blood components A. Type 1 (Ans) B. Type II C. Typeill D. Type IV 13. Which one of tlbe following is the commonly used bulking agent in the fmnnulation of freeze dried low dose drug products ? A. Sodium chloride B. Mannitol (Ans) C. Gelatin D. HPMC 14. The administration of enteric coated products in elderly patients in :some cases is not recommended because A. B. C. D. Decrease in gastric secretion bas been noted in elderly patients (Ans) Intestinal blood flow is reduced in elderly patients Active absorption is reduced in elderly patients Gastric emptying rate is increased in elderly patients 15. Which one of the following properties is desirable in liquid formulations ? A. Thixotropy (Ans) B. Dilatancy C. Syneresis D. Tackiness 16. For accelerated stability testing of drug substances and their formulations intended to be stored in a refrigerator the stability study conditions a.re : A. B. C. D. 25° C ± 2 °C; 60% ± 5% RH for 6 months (Ans) 5°C ± 3°C for 6 months -20 °C ± 5° C for 6 months 40°C ± 2 °C; 75% ± 5% RH for 6 months 17. Which one of the following is the ex-officio member of Pharmacy Council of India ? A. B. C. D. Drug Controller General of India Director General of Health Services Director of Central Drugs Laboratory All of the above (Ans) 18. Which schedule of D&C Act 1940 regulate the manufacture of Blood collection sets ? A. Schedule M-IIl (Ans) B. Schedule F C. Schedule T D. Schedule C-I l 9. Which one of the following is a drug as per Drug and Cosmetic Act? A. Blood (Ans) B. Iodex C. Boumvita D. Boroplus 20. The following are emitted from radjoactive substances EXCEPT the one : A. Alpha particles B. Beta particles C. IR rays (Ans) D. Gamma rays 21. Iodine value oif any oil is indicative of the following characteristic of the oil: A. B. C. D. Level of foee acid present in the oil Level of reducible groups in the oil Level of iodine present in the oil Level of unsaturation present in the oil (Ans) 22. Chlorpbeniramine maleate contents in the tablet sample can be estimated by the following assay method A. Diazotisati.on titrimetry B. Non-aqueous titrimetry (Ans) C. Acid-base titrimetry D. Iodometric titrations 23. Benzyl penicillin can be assayed by the following method: A. Iodimetry (Ans) B. Iodometry C. Bromometric method D. Argentometry 24. The given ttansition is the least energy consuming transition that occurs when a compound absorbs radiations in the UV-Visible range: A. n --t 1t* (Ans) B. 1t --t 1t* C. cr- n* D. cr - cr* 25. When an auxochrome is attached to a chromopboric group, it causes the following change A. Hypsocbromic shift B. Bathocbromic shift (Ans) C. H ypocbromic shift D. Cbemometric shift 26. Presence of a conjugated double bond in a ketone causes the following change in its JR spectrum : A. B. C. D. Decreases the wave number of ketonic group absorption band (Ans) Increases the wave number of ketonic group absorption band Decreases the intensity of ketonic group absorption band Causes no change in the intensity and position of ketone group absorption band 27. In materials where the fracture occurs across the grain, a stronger tablet will be formed from: A. Small granules (Ans) B. Large granules C. Both small and large granules D. None of the above 28.Whicb of the following conditions favor large crystal formation ? A. High degree of supersaturation B. Low nucleation rate (Ans) C. High magma density D. Rapid cooling of .magma 29. Calculate clearance of an antibiotic from the following data obtained after i.v. administration of a bolus dose of the antibiotic: Dose: 200mg Cb0 : Ke : 0.23/hr. 8µg/ml A. 95.83 mUmin (Ans) B. 5.75 Umin C. 2.35 Ubr D. 25.00 L/hr 30. Which one of the following would be an offence in accordance with the provision of the Drugs & Cosmetics Act, 1940? A. B. C. D. Packing of Paediatric oral drops in 30ml pack (Ans) Packing of Oxytocin injection in a single unit blister pack Packing of schedule X drugs in 5ml injection pack Packing of aspirin tablets (75mg) in 14 tablet strip pack 3 l. A product sample of paracetamol tablets claims to contain 500mg paracetamol, but on analysis by Govt. Analyst it is found to contain 200mg of paracetamol. As per Drugs & Cosmetics Act, 1940, this product would be : A. Misbranded drug (Ans) B. Adulterated drug C. Spurious drug D. Unethical drug 32. The mechanism by which micro-organisms are killed by thermal method (wet heat) of sterilization is A. B. C. D. Coagulation of the proteins of the microorganism cells (Ans) Alkylation of essential metabolites of microorganism cells Stopping reproduction of microorganism cells as a result of lethal mutations Oxidation of the proteins of the microorganism cells 33. The effects observed following systemic administration of levodopa in the treatment of parkinsonism have been attributed to its catabolism to dopamine. Carbidopa, can markedJy increase the proportion of levodopa that crosses the blood-brain barrier by: A. B. C. D. Increasing peripheral metabolism of levodopa Decreasing peripheral metabolism of levodopa (Ans) Increasing metabolism of levodopa in CNS None of the above 34. An antimalarial drug containing endoperoxide structure is A. Quinine B. Artemisinin (Ans) C. Quinacrine D. Cycloguanil 35. An agent that covalently modifies COX by acetylating Ser-530 of COX-1 and Ser-516 of COX-2 is: A. Rofecoxib B. lndomethacin C. Aspirin (Ans) D. Diclofenac 36. The common structure amongst the anticonvulsant drugs like barbiturates, succinimides and hydantoins is : A. Sulphonamide B. Ureide (Ans) C. Tbiazide D. Tetrahydropyrimidine 37. The catalytic triead in acetylcholinesterase is composed of the following amino acid residues: A. Serine, Histidine and Glutamate (Ans) B. Serine, Arginine and Glutamate C. Threonine, Histidine and Aspartate D. Threonine. Arginine and Glutamate 38. Which of the following reactions is not a Phase 1 metabolic reaction ? A. Oxidation B. Reduction C. Acetylation (Ans) D. Hydrolysis 39. The palrnitate ester of Chlorarnpbenicol is less bitter tasting than the parent drug because the ester: A. Has lower water solubility (Ans) B. Is more stable to enzymes that degrade it in the gut C. Directly gets absorbed from the buccal cavity D. Is Jess irritating in the moutli 40. Lycopodium spores are utilized for determination of purity of Ginger powder, as a. b. c. d. Ginger powder contains lycopodium spores Ginger powder contains equal number of starch grains as that of Lycopodium spores 1mg of lycopodium spores contains 94000 spores Lycopodium spores are of uniform size and shape: A. False-a: true-b : false-c: true-d B. True-a: fallse-b: false-c: false-d C. True-a: true-b: true-c: true-d D. False-a: false-b: true-c: true-d (Ans) 41. Which one of the following is NOT a steroidal sapogerun? A. Hecogenin B. Diosgenin C. Sarsasapogenin D. Hederagenin (Ans) 42. The value of volume of dist:Iibution for the highly lipophilic antimalarial chloroquine is 15000. Whlch one of the following is correct for high value of volume of distribution of chloroquine? A. B. C. D. Chloroquine is highly bound to plasma proteins Chloroquine undergoes first pass metabolism Chloroquine is highly concentrated in extravascular tissues i.e. liver (Ans) Chloroquine undergoes tubular secretion 43. There is a marked difference in indomethacin terminal half life (t112 = 120 hrs) vs steady state half life (t112 = 2-3 hrs). Which one of the following is the correct reason for the above observation? A. Tubular reabsorption B. First pass effect C. Biliary cycling (Ans) D. Plasma protein binding 44. When the particle size is determined by sedimentation method, the foUowing condition is necessary for free settling: A. B. C. D. Particle size should be more than l 00µm Suspension should not have more than 30% w/v composition Reynold number should be less than 0.1 (Ans) Particles must be perfectly spherical 45. Butylated hydroxytoluene in formulations does NOT act via: A. B. C. D. Blocking formation of free radicals Reacting with the formed free radicals (Ans) Reacting with the formed free radicals Scavenging the free radicals 46. Forward flow test is used for : A. Determining quality of sealing of ampoules B. Testing the integrity and perfonnance of membrane filter (Ans) C. Evaluatio11 of rubber closure performance D. Performance measurement of HEPA filters 47. The plastibase is a popular ointment base because : A. It is having excellent aesthetic feel B. It is good emollient to skin C. It bas a low thermal coefficient relating to better temperature stability. (Ans) D. It is a high quality product having least manufacturing problems 48. In the change -1room of a pharmaceutical manufacturing plant which one of the following is used for band waslb: A. Potable water B. Purified water (Ans) C. Water for injection D. Mineral water 49. Which one of the following drying methods is commonly used in pharma industry for drying of soft shell capsules? A. Truck drying B. Fluid bed drying C. Vacuum drying (Ans) D. Microwave drying 50. Eugenol is present in one of the following crude drugs : A. Fennel B. Tulsi (Ans) C. Cardamom D. Coriander 51. Typically, alkaloids are biosynthesized from: A. Amino acids (Ans) B. Shikimic acid C. Mevalonic acid D. Malanie acid 52. Biosyntbesis of cholesterol proceeds through: A. Mevalonic acid (Ans) B. Shikimic acid C. Chorismic acid D. Malanie acid 53. Alkaloids are mot precipitated by : A. Mayer's reagent f B. Dragendorf' s reagent C. Picric acid D. Mil1011's reagent (Ans) 54. Which of the following alkaloids is derived from tyrosine ? A. Quinine B. Morphine (Ans) C. Atropine D. Ephedrine 55. What is NOT true for tannins? A. B. C. D. They are polyphenolic substances detected by goldbeater's skin test They produce colour reaction with ferric chloride solution They are of hydrolyzable, condensed, pseuodo and complex types Tbey have restricted distribution only in the genera Hamamelis and Quercus (Ans) 56. Whicb of the following plants does not find use in cosmetics? A. Valeriana officinalis (Ans) B. Santa/um album C. Simmondsia chinesis D. Curcuma /onga 57. The type of stomata present in Datura stramonium is A. Anisocytic (Ans) B. Aoomocytic C. Actinocytic D. Diacytic 58. Based on the following microscopic characters of a crude drug powder: Anther cells, parenchyma, poJlengrains, phloem fibers, volatile oil cells and stone ceUs. The powdered drug is inferred to be: A. Clove bud powder B. Clove bud powder with stalk (Ans) C. Mother clove D. None of the above 59.Atracurium, a neuromuscular blocking agent is metabolized through: A. Hoffman elimination (Ans) B. Hoffman rearrangement C. Curtius reaction D. Claisen ScbmidL reaction 60. Milk is deficient in wbicb vitamin? A. Vitamin C (Ans) B. VitaminA C. Vitamin B12 D. VitamioK 61. Oxidation of which substance in the body yields tbe highest amount of calories? A. Glucose B. Glycogen C. Proteins D. Lipids (Ans) 62. Which of the foJlowing ion is required for crystallization and storage of the hormone insulin? C. zn ++ (Ans) D. Ca++ 63. Whicb of the following is amino acid derived antibiotic? A. Azitbromycin B. Streptomycin C. Penicillin G (Ans) D. Tetracycline 64. One of the following anti.hypertensive has a similar structure as that: of diuretic agent chlorthlazide : A. Telmisartan B. Diazoxide (Ans) C. Guanethedine D. Minoxidil 65. Choose the most basic heterocyclic compound among the following: A. Pyrrole B. Pyrrolidine (Ans) C. Furan D. Thiophine 66. Among the following sugars which one is non-reducing sugar and does not exhibit mutarotation? A. Glucose B. Lactose C. Maltose D. Sucrose (Ans) 67. diastereomers possess different physical properties because: A. B. C. D. They are minor images of each other They are conformationally dissimilar isomers Tbey are configurationally similar isomers They are configurationally different isomers (Ans) 68. Some enzymes bind to a non-protein organic molecule for activation, Such a moiety is known as: A. Apoenzyme B. Cofactor C. Coenzyme (Ans) D. Haloenzyme 69. Whicb of the following substances when present in urine is most likely a positive sign of pregnancy? A. B. C. D. Thyroid-stimulating hormone Corticotropin Human chorionic gonadotropin (Ans) Interslitial cell slimulating honnone 70. What is the primary mechanism of action of local anesthetics ? A. B. C. D. Activation of Ligand-gated potassium channels Blokade of voltage-gated sodium channels (Ans) Stimulation of voltage-gated N-type calcium channels Blockade of the GABA-gated chloride channels 71. Increased serum levels of which of the following may be associated with decreased risk of atherosclerosis? A. VLDL B. LDL C. HDL (Ans) D. Cholesterol 72. Drugs that can precipitate bronchial asthma are ? 1. lndomethacine 2. Codeine phosphate 3. Rabeprazole 4. Tbeophylline Choose the correct option: A. I & 3 are correct B. I & 2 are correct (Ans) C. 3 & 4 are correct D. 2 & 4 are correct 73. Corticosteroids are administered to treat (P)Peptic ulcers (R) Nepbrotic syndrome (Q) Bronchial asthma (S) Myasthenia gravis Select the correct combination of statements A. P,Q and S are true while R is false B. P,R and Sare true whileQ is false C. Q,R and S are true whileP is false (Ans) D. P,Q and R are true while S is false 74. All of the given four drugs are neuromuscu.Jar blocking agents. Choose the correct statement about them: (P) Gallamine (R) Decametbonium (Q) Succinylcholine (S) d-Tubocurarine A. P &Q are competitive neuromuscular blocking agents B. Q & R are competitive neuromuscular blocking agents C. R & S are competitive neuromuscular blocking agents D. P & S are competitive neuromuscular blocking agents (Ans) 75. Biowaiver is tlhe concept related to A. Permission for not conducting preclinical testing prior toPhase-I studies B. Permission for not conducting bioavailability in humans C. Permission of using dissolution data to indicate bioavailabiltiy avoiding bioavailability trials (Ans) D. Permission to market the product without bioavailability and toxicity study 76. In case of a drug given as intravenous multiple dose, which one of the following statements is conect: A. The plasm profile is free from fluctuations B. When dose interval is adjusted to biological half life, the ratio of maximum to minimum level is 2 (Ans) C. The constant plasma level is attained after 3rd dose D. It is not possible to cross 2.5 times toxic level by multiple dosing. 77. In relation to sterilization, meaning of D300F =2 minutes is : A. B. C. D. Death of all microorganism ju 2 minutes Death of 300 microorganisms in 2 minutes Death of all microorganisms in 2 minutes at 300°F Death of 90% microorganisms in 2 minutes at 300 °F (Ans) 78. Which one of the following drugs is available as tablet triturate? A. Ephedrine hydrochloride B. Theophylline C. Nitroglycerine (Ans) D. Djgitorun 79. During coating process a porous tablet is likely to show: A. Techiness B. Orange peel effect C. Mottling (Ans) D. Bddging 80. Degradation of ampicillin trihydrate in aqueous suspension follows the following kinetics: A. B. C. D. Apparent .frrst order kinetics Apparent zero order kinetics (Ans) Mixed kinetics Fractional order kinetics 81. Wagner-Nelson method deals with: A. B. C. D. Stability detemunation of a drug in GIT Prediction of ADME behaviour of a drug Calculatiom of absorbed drug (Ans) Calculation of elimination half-life of a drug 82. Fluids that do not flow until a mirumurn shear stress called 'Threshold shear stress' is applied on them, are known as A. Dilatant B. Bingham plastic (Ans) C. Pesudoplastic D. Newtoruan 83. Etbambutol bas : A. B. C. D. Two chiral centers and 4 stereoisomers (Ans) One chiral center and 2 stereoisomers Two chiral centers and 3 stereoisomers Two chiral centers and 2 stereoisomers 84. Particles of stationary phase of Reversed phase HPLC columns are composed of : A. Silica B. Alumina C. Carbon bonded silica (Ans) D. Polyacrylamide 85. One of the following devices is NOT an HPLC detector : A. PDA detector B. Electrochemical detector C. Electron capture detector (Ans) D. Refractive index detector 86. Acetylcholine, a neurotransmitter shows the following type of isomerism in its structure: A. Conformational isomerism (Ans) B. Configurational isomerism C. Functional isomerism D. Positional isomerism 87. Following are the elements of symmetry in organic molecules EXCEPT the one : A. Plane of symmetry B. Alternating axis of symmetry C. Center of symmetry Alternating center of symmetry 88. The given notation used in front of the name of an organic compound means that the compound is dextrorotatory: A. DB. d- (Ans) C. RD. Z- 89. The given compound is an example of pie (x) excessive heterocyclic system A. Quinoline B. Pyridine C. PytTole (Ans) D. Pynolidine 90. The given compound undergoes Diels-Alder reaction under very mild conditions: A. Pyrrole B. Furan (Ans) C. Thiophine D. lmidazole 91. Limit tests of chloride, sulphate and iron are: A. Quantitative tests B. Qualitative tests C. Semi-quantitative tests (Ans) D. Identification tests 92. 6()Co, a radioactive material is used in medicine for the following purposes: A. Theapeutic purposes (Ans) B. Diagnostic purposes C. Experimental purposes D. As a radiotracer 93. Which of the following statements for angle of reposse is true A. B. C. D. Kinetic angle of repose > Static angle of repose Kinetic angle of repose< Static angle of repose (Ans) Kinetic angle of repose = Static angle of repose None of the above 94. lf the glass transition temperature of a polymer is above the room temperature, the polymer behaves at ambient conditions like: A. Glass (Ans) B. Rubber C. Both of the above D. None of the above 95. p-Aminohippuric acid can be used for measuring : A. Glomerular filtration rate (Ans) B. Active tubular secretion rate C. Tubular reabsorption D. None of the above 96. lligh value of gold number means : A. High efficiency of the protective colloids in protecting sensitization and coagulation B. Low efficiency of the protective colloid in protecting sensitization and coagulation (Ans) C. Greater particle size of the colloidal particles D. None of the above 97. Geriatric popuJation should be included in the following Phase of clinical trials: A. Phase I B. Phase II C. Phase ill (Ans) D. PhaseN 98. Which one of the following combinations of temperature and time condition can be employed for steam sterilization by autoclaving A. 115 to 1 l 8 ° C and 30 minutes B. 121 to 124 ° C and 15 minutes C. 134 to 138° C and 3 minutes D. All of the above (Ans) 99. The temperature condition for storage of drug products under cold temperature is given as: A. Temperature between 2° C and 8° C B. Temperature between 8° C and 25° C C. Temperature below 2 ° c D. Temperature at 0 ° C 100. In which one of the following cases the ointment should be sterile ? A. B. C. D. If it is intended for ophthalm.ic use If it is intended for use on large wounds If it is intended for use in severely injured skin AU of the above (Ans)