University:
Liberty University
Course:
BIOM 500 | Introduction to Biomedical Sciences
Academic year:

2024
Views:

286

Pages:

5
Author:

Sheha A.

Protein Structure Proteins are made up of one or more polypeptide chains. Proteins with single polypeptide chain are called monomeric proteins while proteins with 2 or more polypeptide chains are called oligomeric proteins. Each polypeptide chain in an oligomeric protein is called a subunit or monomer. Examples: Hemoglobin, Lactate Dehydrogenase (both have 4 polypeptide chains) All proteins exist as folded structures or 3-dimensional (3-D) conformations which is biologically active. 1) Primary protein 2) Secondary protein 3) Tertiary protein 4) Quaternary protein Primary Structure: Primary structure of protein indicates the number and sequence of amino acids from N-terminal to C-terminal ends. Peptide bonds form the backbone of primary structure. In primary structure, amino acids are arranged in linear chain. The primary structure of each protein has a unique amino acid sequence, determined by their genes contained in DNA. Primary structure is not affected during denaturation (as they are made up of strong covalent bonds). Importance of Primary Structure: Primary structure of protein (specific sequence and number of amino acids) determines the higher levels of protein structure.