Regioselectivity of SN Reactions, Omega Ambident Nucleophiles

Regiosatectivity of SN Reactions. to Ambident Nucleophiles Nucdiophiles electron rich elecbon donare and combine with substrate and gove product. There are some nucleophile in the form group sand than ane having more than Brilic centen molecules and also called infamdicular New Therefore such con react more than one nucleophilec center and form more than one products For exit Some ambident Nu are with the possible products But in commer practice, its impertines is proton. and bases are difened as bases but whenever the acids having So gradually, Blousted Facids and the meechaneum explained by electon's thesey. used which alse explaine Bronsted bases as lears and and respectively of leves concept beronsted acid and Lewis base The trong Nu in highe SN reaction while mild or ever in low con Likewise mon-balas SN² reactions while SN' reaction. So, week N favoure on waction lese polar far polar salvert these factors favours favour seso help in regioselectivity of ambident nucleophile to attack pohticular vecchiophilic denter for example in upuide Nu "Carbon is less slecties negatiue verchiophilic center white visojen lis -gative rudiophilic beady center more dectrone. Carbon cavity to donate its dectron less electronegativity 50. due to it favours waction while I rutigen it moeie electron negatie and comparatively the less nucleophilicity reaction Therefore bonding thoroughh reaction a SN mere holds itse slow donar of electron in favors carbon yanide SN mation of isocyanidi bonding through nitrogen SN' redction come SNI NaN In case of arzanie nucleophilic center (c) than the Nu where both Th of same atom selectivity of will be determine. Nu which high con" form The presence by merchantim lere stable easily first with ite Independent of nucleophilicity high con" Nu mare availlable sund, give SN² reaction The example of B-keto estore malonie ester) such reactiong Ethyl aceto avtale are and in thao competend having sonderbed Hatom and form nedrophilie Sanion when treating strong base For ex- the above Ace Acetoacetic exter can be (ethyl Acets Acetate) Alkylated produced regiestectively oth by ether through-ch brothylene group Howas the electron density of methylene we wil be lessere due to its usonance stabiliss and delocalisation vee at two adjacent become Supphen higher vohile the in Nu of stable dul to delocalisation adjacent stability, the (C) forst 18 available strong Nu O of group pdly at one But due to the high Nu of methylene group more high stable so easily form concentration a Nu undergo SN² reaction while the thyl group ( methyl and form form later like a less stable excess of base so a weak Nu in law concentrate on on undergoes SN' reaction, Theory Acids and bases. Various thearais time and also against the any theory. put forwarded Modified any limitations first to Acid Pand theory of of all time to time to time about frevious the chemistry Base given by acid nd babes Ashenied. The I their chronological order In below Ashenius theory. the acid is the pucton 14t) an while base Acan to Arrhenices theary compound which günle conisation in the (OH-) hydroxyl von in some compounds are soru Juson. aquds compound which geves Aquas soin. aquas so Which show or basis properties but by thes Lonisation theory which become conile But there acidic can't be defined Since thee theo theory to the acids and berses t in aquas solution Bronsted Lowry Theory. This theory bases thre more explain the acids and irrespect of their lonisation. Acen to this theory the compound capable to donate peraton (H+) acts as an ould while the compound capable to accept puston sacts a base this theory periton demars. So, ace to sre Bronsted