University:
Texas A&M University
Course:
BIOL 319 | Integrated Human Anatomy and Physiology I
Academic year:

2024
Views:

228

Pages:

42
Author:

Quintin Ware

Lymphoid System OBJECTIVES PURPOSE OF THE IMMUNE SYSTEM CELLULAR BASIS OF IMMUNITY EFFECTORS OF RESPONSE INDUCTION OF THE RESPONSE ONTOGENY FUNCTIONS OF THE IMMUNE SYSTEM • PROTECTION AGAINST FOREIGN INVADERS INTO BODY • PRODUCE / PROTECT GERM FREE ENVIRONMENT OF THE BODY Thymus 123 Thymus, newborn THYMUS RETICULUM FRAMEWORK - EPITHELIUM EPITHELIUM Lymph node Afferent lymphatic duct Lymph node follicle 1. Germinal center 2. Lymphocyte 3. Reticulum cell Lymph node Afferent lymphatic duct Subscapular space Parafollicular region High endothelial cells of a venule Parafollicular region High endothelial cells of a venule INDUCTION OF RESPONSE •PERIPHERAL ORGAN NEEDED TO GET ANTIGEN AND RESPONSIVE CELL TO INTERACT – LYMPHOCYTE RECIRCULATING – APPROPRIATE CONTEXT Lymphatic sinus in lymph node Venous sinus Medullary cord Lymphatic sinus or Medullary sinus Lymph node medulla: 1. Reticulum cell 2. Lymphocyte 3. Plasma cell Lymphatic sinus or Medullary sinus Macrophages in the lymph node medulla 1. Macrophages Efferent lymphatic duct? Spleen Spleen (reticulum stain)capsule and reticulum fibers Spleen Spleen red and white pulp Spleen: 1. Central artery 2. Periarteriolar lymphatic sheath 3. Red pulp Spleen Marginal zone central artery PENICILLARY ARTERIES Marginal zone Spleen 122 Splenic red pulp: 1. Venous sinus 2. Littoral cell 3. Billroth’s strand Spleen reticulum: 1. Reticulum fiber 2. Billroth’s strand 3. Sinuses Litteral cells of spleenic venial Spleen #19752 (UT117) Tonsil Tonsil Tonsil Esophagus and trachea, monkey Fundic stomach Large intestine or Colon, monkey Plasma cells large intestine in Colon, monkey EM 6 LIFE CYCLE OF LYMPHOCYTES FETAL ORGANS BONE MARROW PRIMARY LYMPHOID ORGANS (ANTIGEN INDEPENDENT DEVELOPMENT) - THYMUS - T LYMPHOCYTES - BONE MARROW - B LYMPHOCYTES SECONDARY LYMPHOID ORGANS (ANTIGEN DEPENDENT DEVELOPMENT) – LYMPH NODES – LYMPHOID NODULES – SPLEEN ONTOGENY •STEM CELLS - BONE MARROW •PRIMARY LYMPHOID ORGANS •SECONDARY LYMPHOID ORGANS •DIFFERENTIATION •TO MATURE •ANTIGEN – •REACTIVE CELLS thymus Bone marrow