Hematopoiesis | The University Of Western Ontario

University:
The University Of Western Ontario
Course:
ANAT 2200B | Systemic Anatomy of the Human Body
Academic year:

2022
Views:

340

Pages:

2
Author:

Kyuwon J.

Hematopoiesis ● Production of new blood cells ● Mainly in bone marrow (after birth) ○ Homeostasis for maintaining RBC, WBC, platelets ● Embryo ○ Yolk sac (1-2 weeks) ○ Liver/Spleen ( 2nd trimester) ○ Bone marrow (after 5 months) ● After birth ○ Red marrow ■ Vertebaer ■ Sternum ■ Ribs ○ Yellow marrow ■ Fatty ■ Inactive hematopoiesis Blood cells ● Myeloid lineages ○ RBC platelets, granulocytes, monocytes ○ Erythopoieissi ■ HSC =>proerythroblast => erythrocytes ■ Stimulation of EPO (kidney) ○ Thrombopoiesis ■ HSC => megakaryocytes => platelets ■ Stimulated in thrombopoetins ● Livers + kidneys ○ Granulopoiesis ■ Neutrophils ■ Eosinophils ■ Basophils ○ Monocytopoiesis ■ Monocytes => macrophages in tissues ● Lymphoid lineages ○ B cells, T cells, NK cells ○ Influenced by thymus and bone marrow ○ T cell and B cells ● Regulations ○ Normal kidney on the right ■ Smooth surface, normal sized (10-12cm) ○ Polycystic kidney ■ enlarged irregular surface ■ Fluid filled cysts scattered in cortex + medulla ■ Parenchyma replace cysts ■ Increase in kidney size (occupy abdominal cavity) ○ PKD = genetic disorder = cause progressive development on renal cyst ○ Cytokines + growth factors ■ EPO => RBCs ■ G-CSF, GM-CSF => stimulation of granulocyte productions ■ IL-3, IL-7, IL-11 ● Fine alignments in pathways