Human Skin Burn Damage | The University Of Western Ontario

University:
The University Of Western Ontario
Course:
ANAT 2200B | Systemic Anatomy of the Human Body
Academic year:

2022
Views:

89

Pages:

2
Author:

Kyuwon J.

Initial Burn damages ● Superficial burns ○ Damage on the epidermis ○ Redness + pain ○ Intact dermis ○ Need epidermal regeneration => without scarring ● Partial thickness burn ○ Effects epidermis and some parts of dermis ■ Blister forms by separation in epidermis and dermis ■ Adnexal structure could be source of keratinocytes ● Hair follicles ● Sweat glands ● Full thickness burns ○ Effects epidermis + dermis ○ Adnexal structure lost ○ Epidermis cannot regenerate ○ Healing is responsible for wound condition Healing phase ● Inflammatory phase ○ 0-3 days ○ Necrotic epidermis ○ Capillary dilations ■ Redness + heat + swelling ● Proliferative phase ○ 4-21 days ○ Karatinocyte migrations ■ Keratinocytes in wound edge ■ Adnexal structures migrates on wound beds ○ Fibroblast activity ■ Fibroblasts (dermis layer) develop in collagen and extracellular matrix ○ Angiogenesis ■ Capillary build up = nourish regeneration tissue ● Re-epithelialization ○ Epidermal cell proliferates = coverup wound surface ○ Forms new stratum ○ Differentiation in suprabasal layer ● Remodeling ○ New epidermis => normally functions ○ Collagen will strengthen the dermis ○ Pigmentation is still not fully recovered Mechanisms ● Stemcell in basal layer + adnexal structure will be responsible on regenerations ● Keratinocytes closing the wound (starting from the edge ● Growth factor stimulates angiogenesis ○ EGF ○ FGF ○ VEGF ● Reinforcement of basement membrane will regenerates dermo-epidermal junctions