Calcium In The Body

Calcium in the Body 991bone teeth 0.91intracellular ER Phosphate in theBody 851Stored in bones teeth 141intracellular It extracellular 0.11 extracellular calciumin circulation 501 unbound 451 boundtoplasmaproteins 5 formcomplexes phosphatebicarbonateCitratelactate Wherecalciumisobtained viathedlett intestinalabsorption Phosphateincirculation 851Circulatefreeunbound 101 boundtoplasmaproteins 5 formcomplexes proteinscarbs lipids WherePhosphateisobtained viathedlett intestinalabsorption absorption intestines absorption intestines unregulated reabsorption reabsorption notabsorbed excretedinfeces resorption bone releasescast excretion feces 800mg unregulated urine 200mg Effects of PTH Calatriol calcitoninonECF parathyroidhormone Tcaztdpoy calcitriol tca2tTPOy calcitonin IcarthPOy BasicstructureofPTH polypeptideproducedinprincipalcells preproPTH pfpFER golgy fetches PTH notabsorbed excretedviafeces resorption bone releasesphosphate excretion feces Soong unregulated urine 900mg BasicAnatomy of Parathyroid Hormone 4looselyorganizedglandsassociated w thyroid externalparathyroid glandoutsidethyroid thanalparatyridgland within thyroid speciesdifferen Cellsof ParathyroidGland principal chiefcellspredominantcelltype PTH hydrophilicunbound incirculation degraded bypeptidases excreted viathekidneys short1 2life Sminutes catstdogs internal others external synthesizePTH oxyphilallsipresentinsmallernumbers functionnotwellunderstood CALCITRIOL 0THReceptors GER linked toast Ggproteins PrecursorMoleculeforcalatriol Synthesis expressed intheplasmamembraneof secosteroidderivedfromUVradiation tenzymate modification ofcholesterol osteoblasts rentbularpelia twosources ofCholecalciferol Vitamin D UVlight UVradiationopenstheBring ofthecholesterolmolecule diet certainspeciesdonotsynthesizevitaminD3intharskin dogs Synthesis ofCalatriol 1st skin last kidney 7 dehdrocholesterol skin UVlight cholecalciferol liver vitaminD3 25 hydroxylase unregulated 25 hydroxyvitaminDCCalafed01 kidney hydroxylase coypu la hydroxylase CYP27131 inactivation 24,25dihydroxyvitaminD ftp.wasewfinatvaton calatrio 1,25 dihydroxyvitamin D activevi Activation BasicStructureofCalatriol secosteroid majority ofVitDarculatesboundtoprotan tahydoxylase kidneys Inactivation VADbindingprotein DBP specific long'lzliseseveralhours renaltubularepithelial Kidney tatty CalatriolReceptor UDR vitaminpreceptor Fuclearhormonereceptorsfoundin osteoblasts Faltublarepitalatts principal once kidney CactivecalcitrioD Flahive 1,2425trihydroxyu calciumandPhosphateRegulation Intestines cat paracellular unregulated transallularregulated bycalcitriol TrpVsTrpV6 catchannels lumen apical membra calbindinkeepscatconclowenterocyte g calcium ATPaseallowscasttoexitbasolateralmembra transportisstimulatedbycalate Kidneys calciumandPhosphateRegulation kidneys Cart PTHandcalcitriolregulatecastreabsorption activetransallulartransport t calbindin Dkeepscatconclowidelivershtasolateral S's iii NeXmorescaltagainstgradient activetranscellulartransport stimulatedbycalcitriol inhibitedbyPTH Éeceptoronbasolateralmembrane stimulatescaltreabsorption enhances casttransporters ofureggy aim UDR in renaltubularepithelialcells stimulatescaltreabsorption ELFCatconcentrations Case on basolateralmembrane ofrenaltubed ECFC.at nhibitscatreabsorptio OTHandCalatrio Regulatepoypeakstrption PTI basolateralmembrane i stimulatesphosphatereabsorption BoneRemodeling constant resorption depositioncanberegulated toprod netgain lossofcast c PTH GPCR calcitonin GPCR slow calatriol calcitriol nuclear Calum GPCR rapid PTH primary PTH calatriol inhibitedby cariolacalaum stimulatedbyPTH secondary alatriol Receptors Calcium parafollicularprincipal renal calcitonin osteoclasts renal PTH parathyroid inhibitedbycalaumecalatriol stimulatedby nothing calcitonin proteinpeptide thyroid Calcium I calcitonin calcium OcalatrioltPTHocalaum n b d d y PTH Calcitriol calcitriol