University:
University of Virginia
Course:
BIOL 1040 | The DNA Revolution in Science and Society
Academic year:

2024
Views:

394

Pages:

3
Author:

Kayli N.

Lecture 3 Polygenic Risk Scores & Personalized Medicine: promises to use genomic data to understand and eventually alter individual health outcomes (immense global effort) ● GWAS: correlate phenotypic variation with SNP variation in a population ○ Generates a polygenic risk score for an individual ● 23andMe and GWAS are essentially the same thing ● Post-GWAS: may involve more than SNPS, to include genetic variation known to influence phenotypes (not there yet) Polygenic Risk Scores for Coronary Artery Disease: translate genomic data into future risk categories for disease. In a public health setting, could save or extend thousands of lives Genetic Risk, Healthy Lifestype, and Coronary Disease: risk score plots don't account for environmental variation (genetics and lifestyle) ● 50,000 healthy lifestyle individuals were tested for 50 SNPs associated with coronary artery disease ● Then assigned to genetic and lifestyle risk scores ● Genetic variation doesn't mean the outcomes are predetermined (genetic essentialism)