PCC2- Cycle 1: Neurological system cycle workshop Psychiatric and Neurological Conditions Workshop Patient E is a 22 year old female; she likes having a lot of make-up and dressed in expensive clothes. Last week, she went to buy a new phone, although her old one is just 3 months old. She started being aggressive with the colleagues in her work and mentioned how influential person she is and she could decide their fate! She had several relationships in the last 4 months that broke down because of her erratic behaviours. Some neighbours have complained to the police as she stays listening to loud music throughout the night. What condition do you think this patient is suffering from? Describe the mechanism of action of Lithium and list the main side effects of lithium What are the positive and negative symptoms of schizophrenia? What are the main side effects of second generation antipsychotics? PCC2- Cycle 1: Neurological system cycle workshop Mrs Jones, 27 years old, has been suffering from Tonic Clonic seizures for the last 10 years. She is currently on Valproate (antiepileptic medication). She is attending an appointment with the neurology consultant after referral from GP as she is planning to become pregnant. She is thinking to stop her medication • Define Epilepsy and mention the main types of epilepsy? • List the signs and symptoms (clinical presentation) of tonic clonic epilepsy • Explain the mechanism of action of Valproate in the management of Epilepsy and which types of epilepsy Valproate is used to treat • What is the difference between an uncoated and gastro-resistant valproate tablet? What are the advantages of a gastro-resistant tablet? PCC2- Cycle 1: Neurological system cycle workshop The consultant decided to change to Lamotrigine, describe the rationale behind the change of valproate to Lamotrigine There are 2 formulations available for lamotrigine, how do they differ in their excipients? Mrs Jones struggles with swallowing tablets, which formulation of lamotrigine could be considered and why? A colleague mentions that Phenytoin has narrow therapeutic index. Explain narrow therapeutic index and its importance PCC2- Cycle 1: Neurological system cycle workshop