University:
West Coast University
Course:
PHAR 837 | IPC Infectious Diseases I
Academic year:

2024
Views:

112

Pages:

2
Author:

Asal A.

**Antiviral Agents (Hughes)** **Influenza** * Neuraminidase inhibitors * Tamiflu - oral * Relenza diskhaler inhaler * Rapivab - IV infusion * Xofluza - single dose, works by cap snatching * Cidofovir - premedicate with probenecid and NS to avoid nephrotoxicity * Acyclovir - thymidine kinase (fill in the blank question) * Valacyclovir is prodrug of acyclovir so it requires less frequent dosing * Abreva - OTC for herpes * Treat within 12h of prodromal symptoms & reduces healing time by 1 day **COVID** * Paxlovid - has renal dose adjustment (eGFR: 30-60mL/min) * Not recommended if eGFR <30mL/min * Remdesivir - indicated for hospitalized pts requiring supplemental oxygen **HIV** * Dolutegravir - stage 4 (integration) * Integrase strand transfer inhibitor * Abacavir - HLA-B*5701 screening * NRTI: associated with lactic acidosis (class side effect) * Two boosters: Norvir (ritonavir) & Tybost (cobicistat) * MOA: inhibit CYP3A4 to increase plasma concentration of protease inhibitors and elvitegravir * When boosting, needs to be taken with food * Nucleoside receptor inhibitors * Viread (tenofovir disoproxil) and Vemlidy (tenofovir alafenamide) * Know difference between Viread and Vemlidy drug, component, side effects (similar to kahoot question) * Baraclude (entecavir) is taken on an empty stomach **HepC** * Know DDI - sofosbuvir with amiodarone is fatal * There are 3 drugs that contain sofosbuvir * Harvoni (sofosbuvir/ledipasvir) **HepC** * Epclusa (sofosbuvir/velpatasvir) * Vosevi (sofosbuvir/velpatasvir/voxilaprevir) **Treatment goal is eradication** * We don't treat active acute hepC, we wait until chronic to treat