Inclusion Body Myositis - Edubirdie

University:
Western Sydney University
Course:
MEDI 3003 | Applied Clinical Sciences
Academic year:

2024
Views:

272

Pages:

1
Author:

Mariam A. A.

Inclusion Body Myositis Age > 50 Chronic Infection NMJ Disease Autoimmune Disease Sporadic Genetic Unknown Autoantibodies **Pathogenesis** Genetic: * Inclusion bodies in muscle fibers * Muscle weakness * Slowed production of proteins * Misfolded proteins * Accumulation of misfolded proteins in muscle fibers * Cell degeneration Sporadic: * Unknown etiology * Similar features but may differ * Inherited form of inclusion body myositis * Many attacks and many affected muscles * Affinity settling on distal muscles (hands & feet) * Difficulty walking or performing daily tasks **Diagnostics** * Muscle biopsy * EMG * CK - elevated * MRI * CPK - muscle enzyme * Inflammatory markers * Muscle biopsy with amyloid or other protein accumulation **Treatment & Management** * Meds: Immunosuppressive therapy * By itself with oral corticosteroids * In combination with other immunosuppressive drugs * Other Interventions * Physical therapy - strengthening * Speech therapy - if dysphagia is present * Occupational therapy

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