TNF Alpha Agents | Western Sydney University - Edubirdie

University:
Western Sydney University
Course:
MEDI 3003 | Applied Clinical Sciences
Academic year:

2024
Views:

84

Pages:

1
Author:

Mariam A. A.

**TNFa Alpha Agents** **Etanercept** * Soluble TNF receptor * Binds to TNFα and prevents it from binding to its receptors * Monomeric antibody * More stable **Infliximab** * Chimeric monoclonal antibody * Binds to TNFα and prevents it from binding to its receptors * IgG1 Fc region * Less stable **Adalimumab** * Fully human monoclonal antibody * Binds to TNFα and prevents it from binding to its receptors * IgG1 Fc region * More stable **Side Effects:** * Infections * Injection site reactions * Headache * Fatigue * Malignancy **Mechanism of Action:** * TNFα is a pro-inflammatory cytokine * It is involved in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease * TNFα inhibitors block the effects of TNFα, leading to a reduction in inflammation and disease activity

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