HBV Serology Notes Serological Tests Interpretation Epidemiology Most people living with chronic HBV in Australia have been infected since birth or early childhood. The two priority populations are: those born overseas in a country with high HBV prevalence (Asia Pacific and Sub-Saharan Africa). Aboriginal and torrest islanders. One third of Australians living with chronic HBV are undiagnosed -> poor outcomes. Primary liver cancer is most attributed to chronic viral hepatitis. Fastest increasing cancer death in Australia. Indications for testing Both in the Asia Pacific and sub-Saharan Africa Aboriginal and torrest islanders. Pregnancy (as need to prevent vertical transmission). Adults at increased risk of transmission, including sexual and household contacts family members of people with HBV, men who have sex with men, people who inject drugs, sex workers and haemodialysis. People with HCV People with HIV. Prescence of co-infection. Patients who are about to commence chemotherapy or immunosuppressive therapy. This is because HBSAg positive patients may develop a life treating flare of HBV when undergoing these treatments.