Recurrent Infections HOPC Associated features: Weight loss Sweating Night sweats Fatigue Shortness of breath Cough Diarrhea Visual changes Skin rashes Chest pain Palpitations Anaemia Focal neurological deficits. Muscle and joint weakness Oral candidiasis Sore throat Lymphadenopathy Meningism. Medications history Medical history Family history Social history Alcohol Recreational drugs Diet Occupation Smoking DO NOT forget about travel history Sexual history History of STIs. Number of patients Gender of patients. Protected sexual intercourse Differentials Chronic diseases e.g. DM Medications Chemotherapy Immunosuppressants Malnutrition Decreased vitamins A, C, D and E, zine, iron, selenium, proteins and carbs -> decreased immune cell formation. HIV/AIDs Fever Fatigue Generalised rash Chronic diarrhea Sore throat Ulcerations Painful swelling Oral hairy leukopenia Oral candidiasis Severe IgA deficiency Common variable immunodeficiency Severe combined immunodeficiency X-linked agammaglobulinemia Low IgG levels DiGeorge syndrome Cardiac abnormalities such as: Tetralogy of Fallot Atrial septal defect Ventricular septal defect Anomalous face Dysplastic ears Cleft palate hypoparathyroidism