Central Node: Inherited Liver Diseases Main Branches: Hemochromatosis Wilson's Disease Sub-Topics and Concepts: Hemochromatosis: 2 types Liver needs to compensate Transberin production Geneke+ More common HEF most common Hepcidin production Regulates iron absorption Undeniably in GIT Peroprotien channels Called fla(a) Deposition Pancieces Iron Hepatoule Bloodsheam Sun TROS Desmonds Bentin ans Membrane in cornea Basal ganglia Hypopigmentation Hepatokcity Direct liver injury ROS Rings ↑ inflammation Skin ↑ myocardial deposition Hepatoruly Cirrhosis Usually chronic Myocardium tuff Islet deposition Portal HIN Cornea Less compliant ↑ Alarossis Vehicles don't want to all in much with blood Cirrhosis with nodulas regeneration ↑ insulin Cognitive impairment Jalaletes Diabetes ↓ albumin Coagulation Diastolic dysf(c) Memory Asciles HF-reshichive Depression Psychosis Jaundice Audiomyopathy Prychiode issues Wilson's Disease: Mutation in ATP7B Copper section in bile Copper binding to apoceruloplasm ↓ copper binding ↓ copper conversion of ceruloplasm ↑ free copper Copper release to blood Splene regulates hepcidin production ↓ hepcidin production ↑ Fe absorption ↑ release to blood Copper deposition Kayser Fleisher rings Movement disorders Dystonia Parkinsonism Cognitive impairment Memory Depression Psychosis Audiomyopathy