Reactions Of Amides - Lecture Notes | Lecture Note - Edubirdie

University:
York University
Course:
CHEM 2021 | Introductory Organic Chemistry II
Academic year:

2023
Views:

212

Pages:

4
Author:

Niklas

Reactions of Amides: Hydrolysis: Ph-C(=O)-NH₂ + H₂O → Ph-COOH + NH₃ Acidic Conditions: H₂O, H⁺ Basic Conditions: OH⁻ 2. Reduction of Amide with LiAlH4 Amide + LiAlH4 + H2O -> Amine 3. Conversion of Amides to Nitriles: R-C(=O)-NH2 + SOCl2 → R-C≡N Reduction of Weinreb Amide → Ketone (R-CO-R) Ph-Cl + HN-OCH3 → Ph-C(=O)-N-OCH3 | CH3 Ph-C(=O)-N-OCH3 + MgBr → Ph-C=O + MgBr-N-OCH3 | | CH3 CH3 **Mechanism:** Ph-C(=O)-N-OCH3 + MgBr → Ph-C(-O-MgBr)-N-OCH3 | CH3 Ph-C(-O-MgBr)-N-OCH3 + H2O → Ph-C(=O)-H + MgBr-OH + HN-OCH3 | CH3

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