University:
Amherst College
Course:
BIOL 220 | Molecules, Genes and Cells
Academic year:

2021
Views:

212

Pages:

16
Author:

boonepanicrtn

If homogametic (XX) If heterogametic (XY) DAX1 (X chromosome) produces anti-testis factor SRY gene (sexdetermining region on Y), inhibits DAX1 induces testes development Ovaries are produced ! Testes are produced " Bipotential gonads SF1 WT1 TESTES Male PGs Female PGs SOX9 AMH Androgens ? ? ? AMH anti-Mullerian hormone Male hormones! "! SRY XY SF1 Androgen receptors! DAX1 Bipotential gonads SF1 WT1 XX OVARIES Male PGs Female PGs SOX9 AMH Androgens ? ? ? DAX1 DAX1 SF1 ? Female hormones! !! "#$$%&'()!! ')*'+',)-!! ./+.0()1%! Steroid hormones •! Produced by gonads, travel through bloodstream •! Androgens –! Testosterone, dihydrotestosterone (DHT), androstenedione •! Estrogens –! Estradiol, estrone, estriol •! Aromatase converts androgens to estrogens Aromatase ! Aromatization of testosterone into estradiol Male (XY)! Female (XX)! Two X’s pair during meiosis X and Y pair during meiosis DAX1 SRY Male (XY)! Female (XX)! Two X’s pair during meiosis X and Y pair during meiosis DAX1 SRY Two X chromosomes in single egg NON TION C N JU -DIS Male (XY)! Female (XX)! Two X’s pair during meiosis X and Y pair during meiosis DAX1 SRY Genotype: XXY! Male (XY)! Female (XX)! Two X’s pair during meiosis X and Y pair during meiosis DAX1 SRY NON TION C N JU -DIS Two X chromosomes in single sperm Male (XY)! Female (XX)! Two X’s pair during meiosis X and Y pair during meiosis DAX1 SRY Genotype: XO Androgen A A Androgen receptor! Androgen A! A! A! A! Mutated androgen receptor! A! Bipotential gonads Male PGs Female PGs SOX9 AMH Androgens ? ? ? SRY XY SF1 DAX1 Androgens AMH anti-Mullerian hormone A SF1 WT1 TESTES Androgen receptor! Male hormones! "! Bipotential gonads SF1 WT1 TESTES Male PGs Female PGs SOX9 AMH Androgens ? ? ? SRY X*Y SF1 DAX1 Androgens AMH anti-Mullerian hormone A Androgen receptor! Male hormones! "! !! Steroid hormones •! Produced by gonads, travel through bloodstream •! Androgens –! Testosterone, dihydrotestosterone (DHT), androstenedione •! Estrogens –! Estradiol, estrone, estriol •! Aromatase converts androgens to estrogens Aromatase ! Aromatization of testosterone into estradiol Male (XY)! Female (XX)! Two X’s pair during meiosis rare recombination b/w the X and Y chromosomes DAX1 SRY Genotype: XX, but with the SRY gene!!!!!! Bipotential gonads SF1 WT1 TESTES Male PGs Female PGs SOX9 AMH Androgens ? ? ? AMH anti-Mullerian hormone SRY XY SF1 DAX1 M!llerian inhibiting substance Androgen receptors! Male hormones! "!

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