University:
Camosun College
Course:
BIOL 252 | Pathophysiology for Nursing 1
Academic year:

2024
Views:

216

Pages:

4
Author:

Aysha A.

✓ ANTI-PARKINSONTAN DRUGS degenaration of Dopamine Containing neuluions in SUBSTANTIA NIGRA deficiency created ↓ cholinergic > dopaminergic neutron auer activity CLASSIFICATION 'DD-MMC' 1) Dreysinfluencing BRAIN DOPAMENERGIC JYS. Dopamine Precusser : Lovadopa. Dopamine agunsst: Bromocriptine MAO-Binhibitors 1 NMDA - Receptor antagonist AMANTIDINE MAU-B inhibitor: SELENGEL INE Catechul-0-Methyltransferase: TUL CAPUNE 2) Dry influencing BRAIN CHOLINERGIC SYSTEM. Centrally Acting Antichitin ergjic - Benzotroptine - Benjo hexol Antihistaminics cuith anati cholinergic Act. - Promethazine - - Diphenhydramine. Levadupa Leva dupa (L-Dupa). Prodrug of main drug in Freatment of Cross BBB Dopamine Parkinson's Poes not cross BBB Laopa decarboxylase ensyone Dupamine {an striatum} Lacton D₂ receptor on Anti Parkinsonian effect Basal Ganglia Iclinical symptoms (rigidity, bradykinesia, tremors) progression of disease is not stopped In persipheral Tissues darge amt of drug is conv. to Dopamine by Peripheral decarboxylase enfyme anly 2-3% enters the bradon (Small amt) so we have reduce peripheral metabolism L Dopa + CARBIDOPA BENSERAZIDE ↓ (peripheral decarkumylase inhib cwhich does not Cross BBB) ↑ availability on Basatganglia. 100 brady lametta: slowness of muroment / speed (progresion) as movement is continued. halts) Peripheral Decarboxylase Inhibitors: CARBIDOPA BENSÆRAZIDE Peripheral decalbury Jure Inhibitors dues not cross In the Periphaly-Inhibit Conv. of L-Dopa Dopamine E at eaty on Persiphary BBB Combinations LDopa + Carbidopa (4:1 or 10:1 ratio) - Co-Careldopa. 1 Dopa + benserazide (4:1 ratio) L Advantages of these combination D↑ broavarlability of dopamine on Basal ganglia 3) ↓ GI effects: Nausea & Vomiting 4) reducel)ers effects tachycardia, pulpitatione hypotension Cardiac artythmia Action of Dopamine on perophary CT2 • Nauser • Vomiting Dopamine Heart & Blood vessel Tach y cardia • Palpitation •Post. hypotension AJE & LEVADOPA: 1) 425: Nausea, Vimiting, anorexia - common. 2) CUS Postural hypotension (DA inbraon sympathetic outflow) •Tachycardia, Pafpitation, rarely Cardiac augthuris 3Dyskinesias (Abnormal suvoluntary movement) 4) Miolination of Faute sensation 5) Mental changes: Insomnia, Confusion, delusion, cupluria, depression