University:
Camosun College
Course:
BIOL 252 | Pathophysiology for Nursing 1
Academic year:

2024
Views:

27

Pages:

4
Author:

Aysha A.

LOCAL ANABSTARTIC. injected locally applied topically Part supplied by a Nerve Block nerve conductron • Cause reversible los of all sensatin axder of blockage Parn temp. Fouch pressure skeletal muscle panel. Classtfiration (1) According to me Surface anaesthetic Ingertable Anaesthetic + • Cocaine • lignocaone short set. • Tetra carne low potency • Benjoceane Rate Aut with intermediate potency Eing Acting arith high potency • Procaine •Lignocaine otetracaine • chlure procatne • mepivalaine •ropovalaine ②According to structure, • articaine a Esters: Cocaine, propaone Amides : lignocatne, mepivacaine. Bsters have 19 amides have 21 Mechanism of Action local anaesthetic (cueak bases) Jissue P1-74 Partly unionised Clipid soluble) Partly runised Penetrate the nerve membrane Bnter the anon Resunisation of local anaesthetic ↑ LA garns access to receptors blocks voltage gated. Bandi more highly Nat channel to enactivated state, Praling the inactivated state Prexcent entry of Nat into reution - decrease rate of depulorisation" ↓ Prevent generation of Action potential ↓ No generation and conduction of impulse to CNS local anaesthesia. LA - Pu dependant Pour Penetration ↳ Renetration ability on Allk. PH (when untossersed form is mure) en brud PH. of tissues ↓ : less effectiven highes hyong først blocked -senzury libves rate *flamed & infected areas. Pyt moker libres block smalles nove Mores first then larger. mere rapid acties myelinated bucked his! hen nin myelinated Pastors offerting weal anaesthesia Pka : Lover Pka the botter ↓ more unionised traction eg: lignocaine me - Pka -7.7 - requod amet of action (3) degree of plasma protein Binding: Highen Prätern bonding a longer duration of Action Procaine Bupivacaine - less bound sturt D.O.A. - mure buurd longer Dioon. 3.) Rate of diffusion bremsite of administration 1 Conc. 2 anset of action high →rapid ermed of Nation 4) lipid Solubility: Soluble Potency mure sol nure Potent ocaine mure potent than procainie lignocaine Is more Foluble 5.) Prescence of vasoconstricter: Prescence of vasoconstrictor - Prolongs action of L-A. Pharmacological Actions Perspheral block Autonomic fibres Nervous then system Cross BBB Cause stimulation Samatic Pain Coma t death large dose Cause depression temp touch muter CNS excitation, trenur, twitching, restlessness, convulsions Pressure louge dose