Hyaline Change and Pathological Calcification | Coventry University

University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2024
Views:

374

Pages:

3
Author:

Badusha S

Hyaline change The refers to an alteration withins cells as as the loctra- cellular space, which gives a homogeneous, glassy, pink appearance in routine histological sections. Couses: 1. Intracellular Hyaline: Mallory body. Mussell bodies. 2. Extracellular Hyaline: Old scans In utesine leiomyoma. Im chronic glomerulonephritis. Patty lives (Steatosis) Gross: Lives enlarges to become yellow, soft & greasy to touch. Microscopy: First fat is seen as small vacuoles in the cytoplasms around the nucleus. The abnormal accumulation of Triglycerides withins the Cytoplains (cytosol) of the parenchymal cells. Causes! Disorders wits hepatocyte damge: Alcohol is the most common cause of fatty change in lives. Disorders with hyperlipidemia. pathogenesis Excessius entry of free fatty acids into the lives. Defective metabolisms of lipid: may the due to the Ised synthesis of fatty acids by the liver. Defective excretion of Lipoproteins. Pathological calcification Abnormal deposition of calcium salts is tissues othes thes asteroid os enansel. It is also associated withs the deposition of Small amounts of iras, magnesium and others minerals. Types of pathologic calcification ane; 1. Dystrophic calcification:- Deposition of calcium dying os dead tissues. Balbh causes: Necrotic tissue calcification is caseous, enzymatic fat necrosis, in dead eggs of Schistosoma, cysticercus and bydd hydatid cysts. Degenerating tissue:- -Heast valves: occurs in aging os damaged heart values. -Atherosclerosis. 2. Metastatic calcification:- Deposition of calcium sallyin apparently warmal tissues. It is associated with hypercalcemia 2 to deranged calcium metabolism. Causes: Increased secretion of parathyroid hormone Destruction of bone tissue. Vitamin Dulated disorders. Renal failures.