Inflammation and Repair | Coventry University - Edubirdie

University:
Coventry University
Course:
B940 | Biomedical Science
Academic year:

2024
Views:

121

Pages:

4
Author:

Badusha S

the sequence of events is an acute inflammation Acute inflammation has 2 major componenti vessels 1. reactions of blood vessels (vascular changes). 2. reactions of leukocytes (cellular events) ng Leukocytic/cellular events The event's can be divided into 2. 1. Leukocyte recruitment 2. phagocytosis and clearance of the injurious agent. 1. Leukocyte Recruitment: tithe process of migrations of centrocytes from the lumes of the vessels to the site of injiny. Steps in leukocyte recruitment; (a) In vascular Lumen: (4) Margination when blood flow slows down, leukocytes towards the peripheral cohemes and accumulate along as the vessels. the andothelial surface. Rodling:- Marginated leukocytes attack weakly to the endothelium, deducts detach and bind again witη a mild jumping movement, causes rolling of along Ane endothelial Surface Leukocytes Adhesions of henhouses: Endothelioms gets activated and leukocytes bind more firmly. (1) Lackocyte migration through vessel wall: (3) Migration throughs endothelium: Migration of leukocytes through the endothelium is called transmigration. os diapedesic... (i) Migration across the basement membrane- ic) outside the vessel wall: Heakougter move in the (Chemotaxis of leukocytes's process of migration of leukocytes boward the inflammatory stimulus in the direction of the chemoattractants. gradient of Locally produced (Accumulation of leukocytes at the sites of infections and injury.

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