University:
Eastern Kentucky University
Course:
BIO 315 | Genetics
Academic year:

2022
Views:

339

Pages:

2
Author:

5prinzg1s

Chapter 16: Genetic and Genomic Testing ____ 1. How is cell-free DNA (cdDNA) testing being used clinically? C. As a less invasive way to determine the characteristics of cancer cells ____ 2. Genetic testing that examines an asymptomatic person’s DNA sequence, looking for mutations that ____ 3. Which tissue is most likely to provide an adequate DNA sample for genetic testing? C. Nasal epithelial cells ____ 4. What type of genetic test provides information about an asymptomatic person’s risk for having a ____ 5. Under which condition can preimplantation genetic testing be performed? A. During in vitro fertilization ____ 6. Genetic testing of an asymptomatic woman whose sister is positive for the mutation that is ____ 7. Which type of genetic testing is the most sensitive method for detecting any mutation in a specific ____ 8. Which type of genetic testing examines a person’s chromosomes for variations in number or ____ increase a person’s susceptibility to a disease, is an example of which type of testing? B. Predispositional testing child with a specific autosomal-recessive disorder in the future? A. Carrier test responsible for an autosomal-dominant disorder that has a 70% penetrance rate would fall into which testing category? C. Predictive predisposition gene? B. Direct DNA sequencing structure? A. Cytogenetic testing 9. How is the polymerase chain reaction (PCR) helpful in the process of genetic testing? D. Increasing the amount of DNA being tested, thus promoting accuracy ____ 10. What is the major disadvantage to the fluorescence in situ hybridization (FISH) method of genetic testing? A. Single-nucleotide mutations cannot be detected. ____ 11. When is fluorescence in situ hybridization (FISH) most likely to be used? B. To determine whether a stillborn infant has trisomy 13 ____ 12. A woman whose sister tested positive for a specific mutation in the BRCA1 gene, which increases the risk for breast and ovarian cancer, is found not to have that mutation but does have a mutation of unknown significance near the known mutation site. How should this woman be counseled? C. She should be informed that she does not have the specific mutation but that because another mutation is present, she should be vigilant about screening. ____ 13. A patient is 34 years old and concerned about possibly being a carrier for HNPCC because his father died of colon cancer at 39, his father’s sister died of colon cancer at age 41, and his brother (aged 37) now has colon cancer. The brother’s testing is negative for all the known mutations associated with inherited forms of colon cancer. How should this patient be counseled about his risk for colon cancer? C. Explain that testing for him would be of no benefit because of the current test limitations but that his family history does place him at high risk. ____ 14. Which genetic-based disorders can be initially identified by the most common types of newborn blood screening? Select all that apply. A. Congenital hypothyroidism C. Galactosemia E. Phenylketonuria F Sickle cell disease