University:
Kentucky State University
Course:
BIO 303 | Human Physiology
Academic year:

2020
Views:

427

Pages:

6
Author:

Athena Harrison

Progesterone & Antiprogestins Biosynthesis: From cholesterol ◼ DE Cholesterol Feedback effects Deh Pregnenolone Progesterone Physiological & Pharmacological effects: - Endometrial differentiation, growth and development. Sudden withdrawal → bleeding (menses) - Maintenance of pregnancy - Breast development - Vagina: ↓ cornification, ↑ mucus content - Cervix: ↑ viscosity ↓ NaCl content - Thermogenic effect - Weak aldosterone-like effect ◼ Absorption & metabolism: Progesterone is available in oral; depo (I.M) injectable and subdermal implants dosage forms ◼ Preparations: Medroxyprogesterone; Norethindrone acetate; Norethindrone; Norgestrel; Megesterol acetate; Hydroxyprogesterone caproate; Cyproterone acetate (Ca prostate); Dydrogesterone (IVF) ◼ Progesterone clinical uses: - Components of OCP’s - Dysfunctional uterine bleeding - Endometrial; breast; prostate cancer - Abortion or maintaining pregnancy - Endometriosis ◼ Progesterone side effects: Depression; weight gain; salt-water retention ◼ Antiprogestins: Mifepristone ◼ Clinical uses: - Abortifacient + PG - Induction of labor + PG - Progesterone-dependent cancer - Cushing’s syndrome ◼