University:
McMaster University
Course:
HTHSCI 1H06 A/B | Human Anatomy and Physiology I
Academic year:

2023
Views:

207

Pages:

2
Author:

Madison Amike

So we already talked about the adverse effects with the drug to drug interaction with antibiotics and oral contraceptives as well as the drug to supplement interaction with St. John Wort and oral contraceptive Now we're going to look at the drug to drug interaction with St. John and Selective serotonin reup take inhibition SSRI like the one sertraline is taking. To preface sertraline is an anti- depressant that as the name suggests works to block serotonin transporter and allow for serotonin to remain in the synaptic cleft for longer. St John’s Wort is an herbal supplement has has been used as a natural anti depressant, much similar to an SSRI as we have mentioned before St. John worth is an inducer and what it does is to induce the CYP450 enzyme and if you remember from class CYP450 - Replace a -CH or -NH group in a molecule with an -OH group and when drugs induces it’s increase the metabolism of a drug as a result causing there to be a decrease in plasma concentration in the co- administer drug, this rendering it ineffective Interestingly enough while it did decrease SSRI, since St. John and SSRI both work to increase the amount of serotonin in the body it lead to what is known as serotonin syndrome Symptoms of serotonin syndrome include severe diarrhea, nausea, vomiting, tremors, shivering, and/or delirium (Serotonin Syndrome, 2025). Connection to case: Naomi mentioned that she was experiencing a stomach flu with vomiting and nausea around three months ago, coinciding with when she began taking the supplement. This could be a result of serotonin syndrome. However, correlation does not equal causation; it could also be related to other factors. So now to answer the question whether is a pharmacokinetic of the job or a pharmacodynamic ● learnedly pharmacokinetic because it involved how the drugs move through the body specifically focusing on the metabolism of the Risk of self medication Naomi's situation highlights the risks of self-medication and the use of non-vitamin, non-mineral (NVNM) supplements. It demonstrates how NVNM supplements can lead to dangerous drug interactions. While self-medication has the benefit of improving accessibility to treatment, it also comes with risks, such as: incorrect dosage, improper method of administration, inappropriate therapy choices, and negative drug-drug or drug-supplement interactions As of general risk of NOn vitamin and Non- mineral interaction ● there’s a a lack fo regulation for nvnm- interestingly enough in canada supplement in canada are label under natural health products and can be considered a drug or food, however despite that y they are still not regulated the way prescription or off the counter medication ● there also unknown safety risks with taking non vitamin and non mineral ● and also while it may increase accessibility it can caused delayed in precision professional care as patient may avoid or discontinue evidence based medication