Mnemonics for Cognition Antipsychotic Drug Side Effects: iSHADE I – Impotence S – Sedation, seizures H – Hypotension A – Akathisia D – Dermatologic effects E – Extrapyramidal symptoms Extrapyramidal Side Effects: Rule of 4s 4 Hours – Acute dystonic reaction 4 Days – Akinesia (Parkinsonism) 4 Weeks – Akathisia 4 Months – Tardive Dyskinesia Schizophrenia Positive Features: THREAD T – Thinking disturbed H – Hallucinations R – Reduced contact with reality E – Emotions A – Agitation D – Delusions, disorganized Schizophrenia Negative Features: Six A’s Atypical Antipsychotics: Rich Queens Are Clumsy Old Zillionaires R – Risperidone Q – Quetiapine A – Aripiprazole C – Clozapine O – Olanzapine Z – Ziprasidone Typical Antipsychotics: H + “-azines” Haloperidol Fluphenazine Trifluoperazine Chlorpromazine Thioridazine Side Effects of Atypical Antipyschotics: Risperidone won't let you rest. Risperidone is associated with increased motor activity. Clozapine closes your cell production. Clozapine causes agranulocytosis. Affect flat Alogia (poverty of speech, slow thoughts) Anergia (loss of energy) Anhedonia (loss of pleasure) Apathy (poor hygiene, disinterest) Asocial (social withdrawal) Olanzapine makes you fat like an O. High Potency Typical Antipsychotics: High aFiniTy (↑ risk EPS) Ziprasidone makes a cutie zzz (sleep). H – Haloperidol F – Fluphenazine T – Trifluoperazine Aripiprazole makes you anxious. Olanzapine causes weight gain. Clozapine, Olanzapine and Quetiapine (C O and Q are the fat alphabets!) cause hyperglycemia, weight gain and hypertriglyceridemia. Ziprasidone causes QT interval prolongation & orthostatic hypotension. Aripiprazole causes anxiety and insomnia due to partial agonist properties.