Pre-eclampsia | The University Of Western Ontario

University:
The University Of Western Ontario
Course:
ANAT 2200B | Systemic Anatomy of the Human Body
Academic year:

2022
Views:

418

Pages:

3
Author:

Kyuwon J.

Pre-eclampsia ● Pre-eclampsia ○ Pregnancy specific ○ Multi-system disorders ■ New onset hypertensions ● 20 week gestations ■ Maternal organ dysfunction ■ Uteroplacental dysfunctions ○ Postpartum may also occur ■ Within 48 hr ■ Is not limited to several weeks Dx ● Hypertensions ○ >140/90mmHg ■ For 2 readings in 4hr ○ >160/110mmHg ■ With several ranges ■ Confirmed sooner ● With one of these followings ○ Proteinuria ■ >300mg/24h urine collection ○ Protein creatinine ratio > 0.3 ○ Dipstick > 2+ ● Maternal end- organ dysfunctions ○ Thrombocytopenia platelets ■ <100,000 ○ Renal dysfunctions ■ Creatinine >1.1mg/dL ■ Double of baselines ○ Liver involvements ■ AST/ALT elevated ■ RUQ/epigastric pains ○ Pulmonary edema ○ Neurologic symptoms ■ Headache ■ Visual symptoms ■ Mental status ● Uteroplacental dysfunctions ○ FGR ○ Abn Dopplers Pathophys ● Abnormal placentation ● Failure on uterine partial artery ○ Remodeling ● Placental ischemia ● Triggering release of anti-angiogenics ○ Inflammatory mediators ○ Systemic endothelial dysfunctions ■ Vasoconstrictions ● Hypertensions ■ Capillary leaks ● Edema ● Pulmonary edema ■ Coagulopathy and platelet consumptions ■ Hypoperfusion of organs ● Kidney ● Liver ● Brain ● Placenta It may look like increase in BP, however it is more of whole body endothelial dysfunction