Vaccination Week #12 | Lecture Note

University:
The University Of Western Ontario
Course:
ANAT 2200B | Systemic Anatomy of the Human Body
Academic year:

2022
Views:

301

Pages:

3
Author:

Kyuwon J.

Vaccination at 12W ● Boost, consolidation of immune response ○ additional and strengthening of week 8 vaccination ○ antibody titer increase and strengthen memory of individual immunologics ● maintaining protection on early infancy ○ infection risk still remains high Vaccines given at week 12 ● DTaP-IPV-Hib ○ second dose ○ acts as booster dosage ○ T-cell enhancement, and dependent responses ○ duration improved ○ magnitude of antibody production has also been improoved ● Pneumococcal Conjugate Vaccine ○ second dose ○ prevention on IPD ○ effective immune memory for infant ● Rotovirus vaccine ○ alike week 8 it is also oral ○ protection against viral gastroenteritis ○ reduction on risk of dehydration ■ and possibly hospitalizations ○ upper age limit ■ dose administration needed ○ Dosing essential regarding safety Ax ● IM ● Oral Why boosters requried? ● Vaccination on week 8 is primary antigen exposure ● ● ● ● ● ● ● ○ initiation of immune recognition ○ low-moderate antibody ○ training of early B/T cells ■ however, the amount is limited 12 week boosters ○ re-exposure of immune system using the same antigens ○ triggering secondary immune response ■ ananestic ○ higher antibody concentration ○ antibody affinity significantly increased ○ immune protection longer lasting infant’s immune system is immature ○ germinal center activity is low (almost none compared to fully grown adults) ○ Low baseline T-cell resp ■ booster dose are essential the speed of response is much faster compared to week 8 dose Week 8 ○ IgM ⇒ IgG Secondary dose ○ predomination of IgG in high affinity Fewer memory cells in week 8, but will have much more memory pool in secondary dose (week 12) If week 8 gave partial protection over antigen, week 12 dose give robust coverage CD4 ● Memory CD4 T-cell recognize MHC-II ○ activation happens rapidly ○ T cell will differentiate into T follicular helper (Tfh) cells ● CD40-CD40L signaling ● cytokine secretion ● B-cell support and maturations