Sinusoids Cheat Sheet | Lecture Note

University:
The University Of Western Ontario
Course:
ANAT 2200B | Systemic Anatomy of the Human Body
Academic year:

2022
Views:

81

Pages:

3
Author:

Kyuwon J.

Sinusoids ● Large irregular vascular channels ○ Usual tubes are about 5-8 um ○ Used as replacement for capillaries in certain organs ■ Liver ■ Spleen ■ Bone marrow ■ Suprarenal glands ● Adrenal ■ Parathroid glands Structure and histology ● Lumen ○ wide , irregular lumens ■ 30-40um ■ Larger than standard capillary ● Wall ○ Tin wall in endothelial cells ■ Large pore ■ No diaphragms in pores ○ Walls are incomplete ■ Includes phagocytic cells if they are on the organs ● Special cells ○ In liver, sinusoids will contain kupffer cells ■ Phagocytic cells ■ Removal of bacteria + foreign particles in bloods ● Surrounding tissues ○ Closely surrounded through organ parenchyma ■ Support rapid exchange of blood and tissue spaces Functions ● Irregular blood flow sluggish ○ More time for exchanges ○ Substances in tissue spaces ● Clinical intuition ○ High yield framing ○ Built in bulk exchanges ■ Larger molecules ■ Cell trafficking for some organs ● Immune cels ■ Typical continuous capillaries ● Does not permit efficiently ● Capillaries ○ Lumen ■ 5-8um ○ endothelial cells ■ Continuous and fenestrated ■ Small pores are closed by diaphragms ■ Arteriols ⇐⇒ venules ● Sinusoids ○ 30-40 um ○ Irregular ■ Wall made endothelial cell and phagocytic cells(but not all of them are made form one) ● Larger pores and slits ● Incomplete ● No diaphragms ■ Connection between arterioles and venules and between venules