University:
University of Cincinnati Blue Ash
Course:
BIOL 5180 | Immunology
Academic year:

2024
Views:

453

Pages:

2
Author:

Jasper J.

Brugia There are two species of wormsBrugiathat causes health problems in humans, namelyBrugia malayiAndBrugia timori. Brugia malayispread across Asia, starting from India, Southeast Asia, to Japan. Brugia adults live in the lymph channels and vessels, while microfilariae are found in the peripheral blood of the definitive host. Brugia Life Cycle Worm Brugiasome are zoonotic parasites, but there are also those that only live in humans. Definitive host Brugia which is zoonotic, apart from humans, there are also various mammals that can play a rolereservoir hosts. Brugiasis malayi has various periodicities, some arenocturnal periodic,subperiodic nocturnal, ornon-periodic, whereasBrugia timoriis nocturnal in nature. The vector that transmits brugiasis is the mosquitoAnopheleswhich becomes a vectornon-zoonotic brugiasis And Mansonia which becomes a vectorzoonotic brugiasis. Clinical Symptoms and Diagnosis Lymphadenitis in brugiasis is different from lymphadenitis in filariasis bancrofti. In brugiasis malayi lymphadenitis that occurs in one inguinal gland can spread downwards (retrograde lymphangitis) and can form ulcers which, when healed, leave characteristic scar tissue. In brugiasis malayi elephantiasis generally only occurs in the lower legs below the knee and rarely occurs in the lower arms below the elbow. InfectionBrugiaalso never causeslymphangitisAnd elephanti as isongenitals And breast.Also kiluria It has never been reported to occur in brugiasis sufferers.A definite diagnosis of brugiasis can only be made after examining the patient's peripheral blood to find microfilariaBrugiawhich is distinctive in shape. Serological tests and immunological examinations are carried out primarily to increase sensitivity in determining early diagnosis of brugiasis. Treatment and Prevention of Brugiasis As with treatment of filariasis bancrofti, DEC is the drug of choice for brugiasis. This drug can be given at a lower dose, namely 3x 0.3-2 mg/kg body weight/day, given for 3 weeks.Prevention of transmission of brugiasis is carried out in accordance with prevention efforts for filariasis bancrofti, namely treatment of sufferers, mass treatment of residents in endemic areas, preventive treatment of immigrants and eradication of vectors that transmit Malayi filariasis.