University:
University of Cincinnati Blue Ash
Course:
BIOL 5180 | Immunology
Academic year:

2024
Views:

257

Pages:

2
Author:

Jasper J.

Life cycle of Plasmodium In the human body and mosquitoes Anopheles on going life cycle Plasmodium. Humans are intermediate hostwhere the life cycle takes place asexual. Meanwhile, inside the mosquito's body, the life cycle takes placesexual.The asexual life cycle consists of four stages, namely stagepreerythrocytic schizogony,stageexoerythrocytic schizogony, stageErythrocytic schizogonyand stagegametogony.In the liver cells, the preerythrocytic schizogony and exoerythrocytic schizogony stages take place in the liver cells, while in the erythrocyte cells the erythrocytic schizogony and gametogony stages take place. - Preerythrocytic schizogony.Sporozoitesplasmodium which enters with mosquito bitesAnopheleswill first enter the cell tissueliver parenchymaand multiply there.OnPlasmodium vivaxThe preerythrocytic schizogony stage lasts for 8 days,onP. falciparumlasted for 6 days,and onP. OvaleThis stage lasts for 9 days.Length of stagePreerythrocytic schizogonyonP. malariaedifficult to determine.In liver tissue, the preerythrocytic cycle inPlasmodium falciparumjust going onone time,whereas in other species this cycle can occur repeatedly (local liver cycle). - Exoerythrocytic schizogony.Local liver cycle is calledexoerythrocytic schizogonywhich is the source of the formation of the asexual stage of the parasite which is the cause of recurrence (relapse) in vivax malaria, ovale malaria and malaria malariErythrocytic schizogony.This cycle occurs in red blood cells (erythrocytes) this lasts for 48 hours onPlasmodium vivax, P. falciparum,AndP. ovale, while onP. malariaetakes place every 72 hours. At stageErythrocytic schizogonythis will happen in formstrophozoites, schizontsAndmerozoiteswhich began to appear 12 days after infectionPlasmodium vivax, and 9 days after infectionP. falciparum.Increased number of malaria parasites due to multiplication in stagesErythrocytic schizogonyresults in the rupture of erythrocytes which causes fever which is typical of the clinical symptoms of malaria (overt malaria). - Gametogony stage.Half ofmerozoiteswhich is formed after the erythrocytic schizogony stage has occurred several times, will develop into a formgametocytes.The formation of gametocytes occurs in erythrocytes found in the capillaries of the spleen and bone marrow. This gametogony stage lasts 96 hours and only mature gametocytes can be producedfound in peripheral blood. Gametocytes do not cause clinical problems in malaria sufferers, so sufferers can act asmalaria career. MosquitoAnophelesis the definitive host for plasmodium because in the mosquito's body the sexual life cycle or cycle takes placeSporogony. -!Gametocytes, OK micro gametocytes nor macro gametocytes which is sucked together with human blood in the mosquito's body will develop into a formgametesand finally it takes shapes porozoites which is infective for humans. To be able to infect a mosquitoAnophelesat least 12 parasites are requiredPlasmodium gametocytesper milliliter of blood. The initial process of parasite maturation occurs in the stomach (midgut) mosquitoes with the formation of 4 to 8 microgametes from one microgametocyte, development from one macrogametocyte to one macrogamete. After fusion occurs between microgametes and macrogametes they becomezygote,within 24 hourszygotewill develop intoookinet.