Study Guide – Cancer Biology

University:
West Coast University
Course:
PHAR 840 | Immunologic Conditions and Special Populations
Academic year:

2024
Views:

252

Pages:

1
Author:

Asal A.

PHAR – 842: IPC Hem/Oncology Study Guide – Cancer Biology: 1. What is cancer? Describe how a cancer cell differs from a normal cell. 2. Compare and contrast apoptosis and necrosis. 3. What are oncogenes and tumor suppressor genes and explain their importance in the process of oncogenesis. 4. Describe different pathways used by cells to repair DNA damage. 5. How does DNA damage contribute to oncogenesis? 6. What is the difference between mutations and DNA damage? 7. Describe the role of cyclins and CDKs in the cell cycle. 8. Describe the role of microtubules in the cell cycle. 9. What physiologic/pathophysiologic process(es) are responsible for mortality associated with cancer? Explain why and describe how cancer progresses. 10. Describe the differences between cancer anorexia cachexia and weight loss due to starvation. 11. Identify the cancer type (tissue and organ of origin) for following cancers • Mammary adenocarcinoma • Diffuse large B cell lymphoma • Colorectal adenocarcinoma • Testicular teratocarcinoma 12. Please write the correct order of prognosis followed by aggressiveness of treatment required for following patients with cancer (from good to bad to worse prognosis) • AB: T1N2G2M0 • CD: T2N1G1M0 • EF: T1N1G1M0 • GH: T3N2G2M0 • IJ: T2N3G3M1 • KL: T3N3+G2M1 • MN: T2N2G3M0 13. Define terms used to describe response of tumors to treatment. • CR • PR • SD • PD • Remission • OS • PFS • DFS • TTP/TTR • DR • ORR 14. Describe in the difference between various grades of side effects for following adverse effects. 15. How is ECOG/Karnofsky score is used in clinical decision making? Study Guide - Sabnis 1