Schizophernia Aflects how people Hunk, feel behave Signs Symptomps, predictor of day b day functioning ↓ among the first appea happer in 80% ptr @ some point Psychoic Ctue hallucinations esp. auditory, delusions esp. pasanuid delusion, delusion of relevence, delusions of control Cbelieving someone is placing thoughtisin their mind, delusions af grandeurų erdoma disorganised speech of thinking Lo word salard #abnormal movement/ disorganised behaviour * inapp,Doriately dressed Prodromal Phase graduas + cognitive-ve Symptoms Negative J defecits in noimal emotions or thoughts J 5 As luniled affect little/ No Omotion alogia speech lacking content Cognitive low attention poor decision maling lack of problem solving avolition no movement asociality anhedonia↓ no desine for social interaction loss of pleasme dunation of untreated psychon's Ty ist episode of psychosis Residual Phare baseline delemines Punchonal oudromes DSM-5 * min 2 of velusions hallucinatio disorganized speech disorganized I catatonic behavior negative symptoms I of theses must be resent active featue for most of the time for ad least I month, with a significant impair-mentor funchioning for at least 6 month Must NOT be due b substance abuse or othe medical conditions schitzoaflechue, biodas, or depressive disorder with psychoke beatues must have been inled out Changes Rom OSMIT no sublyna less emphasis on schmides's hest rank symptomy on't allest patient culkanes Cause unknown, mutblackrid * nevruchemical abnormality Simbalance between dopamine & glutamine. Gpidemidogy 1% * mid 20s 25-mals 27 emales hyf warosivial dop moto, symptoms O mesotanical dap negative symptoms mesolimiric MOL-R tuberoinfurdiola * genches *winde lank postive symptoms * environmental & substance use exp cannabis birth weight, gestational weighl, Dre-eclamps -* emergency - section * urban areas