Barbiturates GABA dependent pathway non-GABA dependent pathway binding sites ove different to benzos NOA bled hypespolarization of post-synaplic neuvons durmation of GABA-galed C charsnel opening intracellular Cr Plove harrower margin to suflety than bersed novial excitability Characterishes *High lipid solubility accumulation in skeletal adipose hissue alutamale signalling rapid omet of action prolonged durrakian of achan memtorane elleds similar to mose of inhalational anesthetics Drugs Indications *Ultra short acting ½ life (is min-3hrs) thiopental, melhohexitaul → 6 general anesthesria 4 status epilepticus sedation for ECT 6↓ of ICP for brain edema following drauma or surgery * short aching ½ life (3-6hrs) pertobabital, secobarbital preanesthetic sedation Is short-term tx for insomnia or anriety disorders 6ersion type headache *Intermediate acting a life (6-12hrs) amobarbital, butalbital Io Same as shoct acting * Long-acting 1/2 life (12-24 hrs) phenobarbital, primidone to generalised-onset foral-onset seizures 6 Phenobarbital status epilepticus neonatal seizures Preanesthetic sedation alkohol withdrawal →Gilbert syndrome ADRS *HOTN (dose-dependent)) *Resp depression lor apnea tolerance withdrawal *CNS depression esp when red with other CUS depressants eg bermas y alkohd *Toxicity cel due istamine * Laryngospasm, brochospasm Myoclonus * interacts with cypuso induction Contradicahons y Porphyria Severe anemia * Fold sons disease * Liver orc disease * Thyroid disease asthma