Conflicting demands on the world are putting
enormous pressure on the chemical industry
Conflicting demands
Social
Population increase
Wealth increase
Climate change
Requirement to reduce
CO2 emissions
By 2050 the chemical industry needs to quadruple
production and cut its emissions by more than half. Maintaining industry growth is essential, since
chemical innovations drive emission reductions in other industries
Example achievements of the chemical industry:
Flourescent lamps
Building insulation foam
Chemical fertilizers
0,7 billion tonnes
2,4 billion tonnes
of GHG saved per year
of GHG saved per year
1,6 billion tonnes
of GHG saved per year Multi-enzyme cascades will become the
next generation of sustainable bioproduction
Cell-free synbio
EziG®
Sustainability
Fermentation
Poor atom
efficiency from living
cells
Traditional chemistry
High energy processes
and fossil fuel
dependency
Process
Efficiency
Cell-free synbio
• Avoids the complexity of fermentation
combined with the efficiency of the
traditional chemistry
• Utilisation of enzyme cascades
outside the cell in an efficient packed
bed reactor, bridging the gap
between two technology platforms. EnginZyme technology: Immobilised enzymes in
well-understood, scalable equipment
EziG immobilised
enzyme cascade
Fixed bed
reactor
EnginZyme cell-free synbio technology
Continuous
process Techno-economic comparison demonstrates
massive cost of production advantage
2 500
Cost of Production
2 000
40% reduction in CapEx
$/MT
1 500
40% reduction in OpEx
70% reduction in Utilities
1 000
40% reduction in Raw Materials
Cost comparison done to FEL-1 standards
500
0
Fermentation
Raw Materials
Utilities
EnginZyme
Manufacturing
Depreciation Cell-free synbio can access the
broadest chemical product suite
Cell-free
synbio
Cell-free
Synbio
Tailored
natural
products
Tailored
natural
products
Classic
catalysis
Classic
catalysis
• Fossil-derived
chemicals
• Fossil-derived
chemicals
• Low
cost,
high
volume
• Low
cost,
high
volume
chemicals
chemicals
Enzyme
catalysis
Enzyme
catalysis
• High value products
• High value products
• Chiral compounds
• Chiral compounds
Fermentation
• Natural products
• High value products
• Bio-based products
Example addressable markets:
▪ Paints & Coatings: $105bn
▪ Agrochemicals: $55bn
▪ Cosmetics ingredients: $8bn
▪ Fermentation fine chem:$25bn
▪ APIs: $166bn
▪ Solvents: $50bn
▪ Household cleaners: $30bn
▪ Sweeteners: $14bn
▪ Plastics: $520bn
▪ Polymers: $700bn
▪ Cement: $500bn
Conflicting Demands on the World are Putting Enormous Pressure on the Chemical Industry
of 7
Report
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