University:
Boston University
Course:
CAS EE 645 | Physical Models in Remote Sensing
Academic year:

2023
Views:

357

Pages:

9
Author:

SpaceCadet101

Health Effects of PCEContaminated Drinking Water PCE in Cape Cod Waters      Commercially important solvent and common contaminant PCE leached into drinking water supplies of Cape Cod from vinyl lining in water distribution pipes ~400 miles installed 1968-1980 Problem discovered in 1980 Concentrations up to 7,750 ug/l Unique Exposure Scenario     Large population was exposed (15%) Wide range of exposure levels in an environmental setting Irregular contamination pattern Little confounding by other contaminants and population characteristics Superfund Research I. Case-control Study of Breast Cancer II. Cohort Study of Reproductive and Developmental Outcomes III. Cohort Study of Neurotoxic Effects Mature epidemiological research program -Extensive subject data -Geographic Info System -Project 2 collaboration Refined Exposure Assessment     Validation Study EPANet software Personal Dose Estimates Method Papers and Reanalysis PCE Cohort Study, Parts 1 and 2   Large number of exposed and unexposed families, including parents and children (n=5,000) Variety of Exposures – Prenatal and postnatal combined – Postnatal only – Adult mothers and fathers PCE Cohort Study, Part 1  Questionnaire data on “gross” reproductive and developmental effects – Low birth weight – Premature birth – Miscarriage/stillbirth – Birth defects – Developmental disorders of learning and attention PCE Cohort Study, Part 2 Focus on “subtle” neurological effects     Neuropsychological testing (n=300) Vision exams (n=300) Structural (n=120) and functional MRIs (n=60) Many disease outcomes from mail questionnaires (n=5,000) Future Plans   Analyze collected data Follow-up positive associations in smaller, focused investigations – Nested case-control studies – Neurotoxic effects, esp. NP and vision tests, imaging data – Other outcomes: cancer, birth defects