Characterization of A Subcutaneous Bleb Model | Research - Edubirdie

University:
Boston University
Course:
GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management
Academic year:

2024
Views:

219

Pages:

1
Author:

Naomi Whitehead

Characterization of A Subcutaneous Bleb Model Subcutaneous large volume infusions play a critical role in drug therapies that require continu-ous delivery at low dosages. Delivered into adipose tissue underneath the epidermis and dermis, subcutaneous injections provide many advantages over intravenous administration, including of-fering the possibility of at-home treatment, reducing user error and reducing overall care costs. Despite these advantages, subcutaneous administration of large volume infusions can lead to the formation of blebs that produce concentrated pressure, further leading to complications for pa-tients receiving treatment. When utilizing subcutaneous injection volumes greater than 1 mL, these complications from bleb formation can include injection pain, high subcutaneous back pressure, leakage and reactions at the injection site. Current research on the formation of subcutaneous blebs is primarily performed through costly and laborious animal studies. Furthermore, these ani-mal studies generally lack in providing sufficient quantitative data for analysis. To solve the issues associated with conventional animal studies, a three-part in-silico computer model was developed by Takeda Pharmaceuticals with the goal of assessing the contributing factors in predicting patient complications from bleb formations. The current computer modeling relies on the assumption that human subcutaneous tissue is a uniform space, which is not representative of real-world data and was unable to reproduce in vivo testing results. By conducting ex vivo studies utilizing proprietary subcutaneous modeling, we propose research guided solutions to flaws associated with Takeda’s current computer model. Results of the conducted ex vivo studies are ultimately leading to more robust in silico modeling, capable of providing a novel and efficient alternative to in vivo testing of large volume infusion therapies.

Related Documents

Characterization of A Subcutaneous Bleb Model

Recommended Documents

Wire Feeder Awareness Reminder

Wire Feeder Awareness Reminder

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Cheat Sheet

Pathways for Emotions and Memory

Pathways for Emotions and Memory

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

Causes and Consequences of Urban Hospital Closings and Reconfigurations Pt 2

Causes and Consequences of Urban Hospital Closings and Reconfigurations Pt 2

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Lecture Note

Prenatal Choline Deficiency Increases Choline Transporter Expression in the Septum

Prenatal Choline Deficiency Increases Choline Transporter Expression in the Septum

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

The Ways We’ve been Measuring Patent Scope are Wrong (Appendix)

The Ways We’ve been Measuring Patent Scope are Wrong (Appendix)

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

Adolescents and Adults with Autism A Study of Family Caregiving

Adolescents and Adults with Autism A Study of Family Caregiving

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

Massachusetts Acute Hospital Costs in 1989 Were $1.75 Billion in Excess of the Level

Massachusetts Acute Hospital Costs in 1989 Were $1.75 Billion in Excess of the Level

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

Direct-to-Consumer Advertising of Pharmaceuticals

Direct-to-Consumer Advertising of Pharmaceuticals

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

The Ways We’ve been Measuring Patent Scope are Wrong (Tables and Figures)

The Ways We’ve been Measuring Patent Scope are Wrong (Tables and Figures)

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

The Ways We’ve been Measuring Patent Scope are Wrong

The Ways We’ve been Measuring Patent Scope are Wrong

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

Direct-to-Consumer Advertising of Pharmaceuticals (Appendix)

Direct-to-Consumer Advertising of Pharmaceuticals (Appendix)

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

New Documents from this Course

What is Public Health Lecture Part 2

What is Public Health Lecture Part 2

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Lecture Note

The Effect of Magnesium on Dentinogesis of Human Dentalpulp Cells

The Effect of Magnesium on Dentinogesis of Human Dentalpulp Cells

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Lecture Note

Policy Coherence, Health and the Sustainable Development Goals a Health Impact Assessment of the Trans-Pacific Partnership

Policy Coherence, Health and the Sustainable Development Goals a Health Impact Assessment of the Trans-Pacific Partnership

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

Flow Arrest Intra-arterial Delivery of Small TAT-decorated

Flow Arrest Intra-arterial Delivery of Small TAT-decorated

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

What is Public Health Lecture Part 3

What is Public Health Lecture Part 3

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Lecture Note

Higher Rhodopsin Levels Enlarge Diameter of Rod Photoreceptors in Mouse Retina

Higher Rhodopsin Levels Enlarge Diameter of Rod Photoreceptors in Mouse Retina

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Lab

Functional Neuroanatomy of Time-To-Passage Perception

Functional Neuroanatomy of Time-To-Passage Perception

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

Impairment vs.Function in Aphasia Chapter 5

Impairment vs.Function in Aphasia Chapter 5

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Case

An Optical Device for the Detection of Counterfeit and Substandard Antimalarial Drugs

An Optical Device for the Detection of Counterfeit and Substandard Antimalarial Drugs

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Cheat Sheet

Spontaneous Default Network Activity Reflects Behavioral Variability Independent of Mind-wandering

Spontaneous Default Network Activity Reflects Behavioral Variability Independent of Mind-wandering

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research

What is Public Health Lecture Part 4

What is Public Health Lecture Part 4

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Lecture Note

Neural Activity Underlying the Detection of an Object Movement by an Observer During Forward Self-motion Dynamic Decoding and Temporal Evolution of Directional Cortical Connectivity

Neural Activity Underlying the Detection of an Object Movement by an Observer During Forward Self-motion Dynamic Decoding and Temporal Evolution of Directional Cortical Connectivity

Boston University GMS BC 630 | Ethical & Policy Issues in Health and Medical Services Emergency Management

Research