University:
Boston University
Course:
SAR HP 151 | Introduction to Health Professions
Academic year:

2024
Views:

259

Pages:

1
Author:

devoespken

Modeling Ramifications of Synaptic Degradation on Auditory Recall in Wernicke’s Aphasia 5 Introduction Results Wernicke's area is located in the temporal lobe and is required for comprehension Wernicke's aphasia (WA) is caused by stroke, TBI, encephalitis, and more WA is fluent and disrupts comprehension and the ability to form intelligible responses Individuals often have literal/semantic paraphasia or schizophasia ("word salad") Unable to communicate, those with WA suffer from ceaseless isolation and a high risk of mental health disorders. Wernicke’s Area. (2017, September 19). You Know Your Brain: Wernicke's Area. https://www.neuroscientificallychallenged.com/blog/knowyour-brain-wernickes-area WERNICKE'S AREA MOTOR CORTEX BROCA'S AREA TYPICAL SIMILARITY % “In the morning, I ate cake and went swimming with my dogs.” 100% “In the summer, we ate lemonade and went running with your whale.” DEGRADED 77.15% Figure 3 Neurons Activated vs. Sentence Accuracy Methods Step 1. Define categories Step 2. Convert each word to a binary vector* made of 1s and 0s Step 3. Alter each vector through a degraded connectivity matrix Step 4. Use cosine similarity to associate the modified vector and a predefined word (Figure 1) SIMILARITY Figure 1 = cos(θ) = A B A B Step 5. Assess results and collect data Step 6. Return the manipulated sentence *A vector in ndimension space can represent the activity of n neurons Figure 2 Figure 1 = n ΣAi Bi Neurons Activated (%) Formula: f(x) = logₐx where a ≈ 1.032 Figure 4 Figure 5 i=1 n n ΣAi ΣBi i=1 2 i=1 2 Discussion The results support that a loss of neural connections in Wernicke's aphasia is correlated with a drastic decline in language comprehension and subsequent speech production. Significance This information can be used to: Develop potential therapies and rehabilitation programs Create technologies that isolate paraphasia and decode sentences Understand the relationship between neuron activation and language comprehension Model the auditory processing system in greater depth Future Experimentation Continue semantic paraphasia-specific testing and initiate literal paraphasia-specific testing Test the effects of inhibitory neurons on language comprehension Reverse the process to correct a schizophasic sentence Accuracy (%) AUDITORY CORTEX “In the morning, I ate cake and went swimming with my dogs.” Conclusions The degraded connectivity matrix distorts the input sentence to produce a modified output emulating Wernicke's Aphasia (Figure 3) Each word has a vector parallel for computing neural degradation, and each word belongs in a larger category to model association in neural pathways (Figure 5) The vectors are all an 8-byte binary NumPy array The program ran 1,000 simulations comparing the neurons activated vs. the similarity of the sentences to generate a logarithmic growth curve (logₐx where a ≈ 1.032) (Figure 4) Both the x and y values are measured in percentages This curve indicates that a decrease in neural activation causes a decline in language comprehension