Hunting the Nightmare Bacteria Worksheet

Microbiology Hunting the Nightmare Bacteria Addy 1. What did doctors believe Addy was infected with initially? Methicillin-resistant Staphylococcus aureus (MRSA) and pneumonia 2. What were her symptoms? Pain in her hip and fever, had infected boils all over body 3. Addy had ‘community-acquired’ resistant staph (as opposed to hospital-acquired). How did Addy likely become infected initially? In a school playground or playing softball and scraped her leg-she picked at her scabs on her skin and which introduced the staph infection 4. What secondary infection did Addy acquire in the hospital? How did she acquire it? Stenotrophomonas due to bacteria living in the tubes of ECMO 5. What does pan-resistant mean? Resistant to everything -The more antibiotics are used, the more resistant the bacteria can become because sensitive bacteria are killed, but stronger germs resist the treatment and grow and multiply. 6. What have been the lasting effects of Addy’s infections? She has to take pills everyday, has reoccurring pneumonia, and has to deal with the deadly side effects of a lung transplant. David 7. How was David Ricci injured in India. He was infected with CRE (carbapenem-resistant enterobacteriaceae). What gene invokes this type of resistance? speed of train hooked his sleeve and ran him over and dragged him underneath the train. The wheel ran over his leg, which massively injured his leg which was ultimately cut off at the hospital; NDM-1 enzyme or a resistance gene that can jump from one bacteria to another 8. Are bacteria with the NDM-1 gene found in the environment? Yes; could be found in water especially third world countries 9. About how many other types of resistant bacteria did they find? 11 10. If a spreading infection cannot be cured, what has to happen? They need to surgically cut out the infection tissues Clinical Center at the National Institutes of Health (NIH) 11. In 2008, a patient in ICU was diagnosed with KPC (Klebsiella pnuemoniae carbapenemase-producing) at the Clinical Center at the National Institutes of Health (NIH). Five weeks after the patient was released, KPC turned up in a respiratory culture. They had asymptomatic carriers that were passing it onto others, meaning that is was already all over the hospital before the outbreak began Do they know how it was spread? Were they able to get rid of it at that time? They had asymptomatic carriers that were passing it onto others, meaning that is was already all over the hospital before the outbreak began; No 12. Six months after patient #1, there was another outbreak. How many patients were infected and how many died? 18 patient were infected with 6 deaths and in 2013 -7th person died Antibiotics 13. The more antibiotics are used, the more become. resistance 14. Alexander Fleming, the discoverer of penicillin saw resistance as early as they 1945 15. Up to 1/3(one-third) of antibiotic use is inappropriate. 16. Why is it more lucrative for drug companies to develop drugs for chronic illnesses than antibiotics? . Cause chronic condition mediations are taken daily and bring in more revenue than antibiotics which you typical take only 5-10 days if you have an infection 17. Approximately how much does it cost to bring a new drug to market? Up to 1 billion dollars 18. The CDC estimates: a. Number of people infected with resistant bacteria? 200- By 2050, superbugs could kill 10 million people a year. b. Number of people that have died? 7