University:
Liberty University
Course:
BIOM 500 | Introduction to Biomedical Sciences
Academic year:

2024
Views:

498

Pages:

5
Author:

Sheha A.

Lipoproteins Lipoproteins are the transport form of lipids in the blood. Lipids are water-insoluble compounds. Lipids are made soluble by combining with proteins to form lipoproteins. Proteins The protein part of the lipoprotein is called apolipoprotein. Lipoproteins contain a variety of lipids: triglycerides, cholesterol esters, and cholesterol. Lipoprotein Classification Based on the density Based on electrophoretic mobility Based on size Lipoproteins are divided into 4 classes: Chylomicrons VLDL (Very low-density lipoprotein) LDL (Low-density lipoprotein) HDL (High-density lipoprotein) Lipoprotein Classification Based on density: Chylomicrons - density is 0.94-1.006 g/ml (Very low-density lipoprotein) VLDL (Very low-density lipoprotein) - density is 0.96-1.006 g/ml LDL (Low-density lipoprotein) - density is 1.006-1.063 g/ml HDL (High-density lipoprotein) - density is 1.063-1.21 g/ml Based on electrophoretic mobility: Chylomicrons at pre-beta region VLDL moves to the pre-beta region, hence VLDL is also called pre-beta lipoproteins LDL moves to beta-region, hence LDL is also called beta lipoproteins HDL moves to alpha region, hence HDL is also called alpha lipoproteins Apolipoproteins Apolipoproteins are proteins combining different lipoproteins. Chylomicrons: Apo A, Apo B-48, Apo C, Apo E VLDL: Apo B-100, Apo C, Apo E LDL: Apo B-100 HDL: Apo A, Apo C, Apo E