University:
Liberty University
Course:
BIOM 500 | Introduction to Biomedical Sciences
Academic year:

2024
Views:

30

Pages:

5
Author:

Sheha A.

Plasma Proteins Plasma: It is a liquid medium of blood in which the cell components namely erythrocytes, leukocytes, platelets are suspended. If the blood containing anticoagulants is centrifuged, the plasma separates as a supernatant while the cells remain at the bottom. Serum: It is the term applied to the liquid medium which separates out after blood clots. Serum does not contain fibrinogen and other clotting factors. Fractions: Albumin, globulins and fibrinogen are three important classes of plasma protein. The normal range of plasma protein in blood are: Albumin: 3.5-5 g/dL Globulin: 2.5-3.5 g/dL Fibrinogen: 200-400 mg/dL Albumin It is the major plasma protein. It is 60% of plasma proteins. It is synthesized in the liver. Globulin Globulin comprises the much smaller fraction of the total protein. It constitutes many different proteins which are separated into 4 distinct bands in electrophoresis. Each band contains various globulin proteins. α1 globulin - retinol binding protein (RBP), α1-antitrypsin α2 globulin: ceruloplasmin, prothrombin β globulin: LDL, transferrin, plasminogen β-γ globulin: Immunoglobulin Fibrinogen: Fibrinogen is a protein produced by the liver. These are responsible for coagulation.