Metabolism of Lipids | Lecture Note

University:
Liberty University
Course:
BIOM 500 | Introduction to Biomedical Sciences
Academic year:

2024
Views:

393

Pages:

5
Author:

Sheha A.

Metabolism of Lipids Digestion: Fats are digested in the small intestine. Triglycerides upon digestion yield fatty acids and monoglycerides. For fats to be absorbed, a molecule of diglyceride is first hydrolyzed by lipase to glycerol and fatty acids. Absorption: Fatty acids and glycerol enter the bloodstream. From the bloodstream, fatty acids are picked up by the cells of tissues and compose tissues. Fats are also used as fuel for energy production. Intestinal mucosal cells are also involved in fat absorption. Lipolysis Complete dissociation of triglycerides by lipase is called lipolysis. Lipases are the lipolytic enzymes. Fate of Glycerol: Glycerol released by lipase enters the glycolysis pathway. Then, it is phosphorylated to glycerol-3-phosphate. Glycerol-3-phosphate is oxidized to dihydroxyacetone phosphate. The glycolytic enzyme triose phosphate isomerase converts dihydroxyacetone phosphate, which is then oxidized by glycolysis.