University:
Liberty University
Course:
BIOM 500 | Introduction to Biomedical Sciences
Academic year:

2024
Views:

82

Pages:

5
Author:

Sheha A.

**Fate of Palmitic Acid** Palmitic acid is the product of fatty acid de novo synthesis of fatty acid that occurs in the cytosol. It may be used for: * Chain elongation or esterification to triglycerides **Chain Elongation** 2 systems for the synthesis of long-chain fatty acid from palmitate: 1. Microsomal elongation system 2. Mitochondrial elongation system **Microsomal elongation system** * This is thought about by specific enzyme elongase. * This system is similar to fatty acid synthesis system and uses malonyl-CoA and NADPH. * C20 and C24 fatty acids are synthesized by this system. **Mitochondrial elongation system** * This system uses acetyl-CoA or acetoacetyl-CoA and utilizes NADH. This is less active. **Desaturation** The double bonds are introduced by microsomal enzyme that is fatty acyl desaturase and uses NADH and molecular oxygen. **Es-synthesis of oleic acid from stearic acid and palmitoleic acid and palmitic acid** **Esterification** The palmitic acids formed are also esterified with glycerol to form fats. **Diseases related to lipid metabolism** 1. **Steatorrhea:** * Mal-absorption of fat due to inadequate secretion of pancreatic lipase or bile salts or due to intestinal diseases like celiac disease. * Results in increased excretion of fat in the feces. 2. **Obesity:** * Accumulation of excess of body fat. 3. **Lipidosis:** * Abnormal accumulation of specific lipids in tissues.