Review Test Submission Lecture 2 Quiz Innate Immunity 1

Review Test Submission: Lecture 2 Quiz: Innate Immunity 1 Question 1 1 out of 1 points Which of the following innate immune response statements is false? Selected Answer: b. Results in the production of pathogen-specific antibodies and long term memory. Answers: a. Surface receptors of innate immune cells recognise pathogen associated molecular patterns. b. Results in the production of pathogen-specific antibodies and long term memory. c. Innate immunity enables rapid/immediate responses to invading pathogens. d. Includes internal defences such as phagocytosis of invading pathogens by innate immune cells. Answer Feedback: Question 2 Correct, this statement is false. Antibodies are produced by plasma cells during adaptive immune responses. Which of the following statements is true for antimicrobial peptides (AMP)? Selected Answer: Answers: c. Perforate bacterial membranes to induce lysis. a. Enhance phagocytosis. b. Preferentially bind eukaryotic membranes. c. Perforate bacterial membranes to induce lysis. d. Enhance phagocytosis and preferentially bind eukaryotic membranes. Answer Feedback: Correct, AMPs oligomerize to create pores in bacterial membranes leading to lysis. Question 3 1 out of 1 points Which of the following statements is specific to gut chemical barriers? Selected Answer: Answers: a. Specialized enzymes such as pepsin. a. Specialized enzymes such as pepsin. b. Antimicrobial peptides. c. Lysozymes. d. None of the above. Answer Feedback: Correct. Pepsin is an example of a specific gut chemical barrier. Question 4 0 out of 1 points Which complement pathway becomes activated by spontaneous hydrolysis of C3? Selected Answer: Answers: d. Both options a & b are correct a. Classical b. Alternative c. Lectin d. Both options a & b are correct Answer Feedback: Incorrect, only option b is correct. Question 5 0 out of 1 points Complete the following sentence. The cleavage of C3 and C5 results in the production of C3a and C5a fragments which are....... Selected Answer: a. fundamental for the establishment of the membrane attack complex (MAC). Answers: a. fundamental for the establishment of the membrane attack complex (MAC). b. inactive molecules. c. opsonizing agents. d. anaphylatoxins. Answer Feedback: Incorrect, C3a and C5a fragments are not involved in MAC. Question 6 1 out of 1 points Which of the following statements is true for Neutrophils? Selected Answer: Answers: b. Are the most abundant white blood cell (WBC) in peripheral blood. a. Emigrate to tissues and become resident neutrophils with specialized functions. b. Are the most abundant white blood cell (WBC) in peripheral blood. c. Are the most efficient antigen presenting immune cell (APC). d. Kill virally infected host cells by forming pores in their extracellular membrane. Answer Feedback: Correct, neutophils comprise 30-70% of peripheral WBCs. Question 7 1 out of 1 points Which of the innate immune cells below are not phagocytic? Selected Answer: a. Lymphocytes Answers: a. Lymphocytes b. Neutrophils c. Dendritic cells d. Macrophages Answer Feedback: Correct, as lymphocytes are not innate immune cells. Question 8 1 out of 1 points Which of the following statements best describes the classical complement pathway effector function? Selected Answer: Answers: d. All of the above. a. Inflammation. b. Pathogenic lysis. c. Opsonisation. d. All of the above. Answer Feedback: This statement is the most correct. The activation of any of the classical complement pathways can give rise to the above effector functions. Question 9 1 out of 1 points Which complement component is involved in all complement pathways? Selected Answer: Answers: b. C3 a. C9 b. C3 c. C1q d. C4 Answer Feedback: Question 10 Correct, all complement pathways converge at the generation of C3 convertase. 1 out of 1 points Which of the following options best describes an opsonising agent? Selected Answer: Answers: d. All of the above. a. Surfactants. b. Antibodies. c. C3b. d. All of the above. Answer Feedback: Correct, All of the responses above are examples of Opsonins. Question 11 1 out of 1 points Which is the least abundant granulocyte in peripheral blood? Selected Answer: Answers: a. Basophils. a. Basophils. b. Mast Cells. c. Neutrophils. d. Eosinophils. Answer Feedback: Correct, basophils constitute 0.1 – 0.3% of WBCs. Question 12 0 out of 1 points Which innate immune cell efficiently kills antibody coated parasites? Selected Answer: Answers: c. Neutrophils. a. Macrophages. b. Eosinophils. c. Neutrophils. d. Basophils. Answer Feedback: Incorrect, neutrophils have potent antibacterial action. ← OK