University:
McMaster University
Course:
BIOLOGY 4T03 | Molecular and Cellular Neuroscience
Academic year:

2021
Views:

153

Pages:

1
Author:

Sabrina S.

Chapter 2 02/7/2021 Opiates Indirectly Trigger the release of Dopamine Endogenous opioids have important roles in behavior including regulation of normal social behaviors (eg mother-infant bonding, mate Attachement, desire for social contact, and the management of pain) *while there are many opioid receptors in the serain, it is the stimulation of the mu receptor that is critical for the rewarding properties of the plant opiates heroine and morpheme Le the mu receptor induces necmuraine hyperpolarization (similar to D2 D4 ECCCpron) that muits in the blocking of the spinomesencephalic ascending poin pathway Natural opioid or clinical oplate stimulation of mu receptors stops the signal in the mesencephalon before it can reach the cortex the clinical usefwness is limitsa to Just a few days because spiciaL CRUSE release of popamine in the stward centers. Cannabinoids Interact with opioid and feeding pathway ★Marijuana is the most commonly abused illicit drug in the united states The main active chemical in marijuana 16 THE. The membranes of nerve cells in the hippocampus and hypothalamus contain pratein receptors called 683 Γεεερτους that wind to the once in prace, The activates a series of presin mediamus reactions that lead to euphoria The cos receptors in της paraventricular hypomasamus arc linked to the munchies The CB1 receptor innilents reicase of glutamats. The mhibition of gintamare reicase gives marijuane its analgesic qualities because glutamate is the expitarony neurotransmitter that is wied to carry nociceptive signais to the brain those blocked by the mu receptors) THE stimulation of cas recepters in the hippocampus and the subsequerre mnibition of glutamats release is believed to be the neuronal basis benina marijuana causing or worsening probems te depression, amuenry, and personality disturbances. If 681 is activated WIR stop the release of glutamate, GABA, dopamine, Serotonin and acetylcholine anxiety gsmare